01. PROMO
What's New in MonolixSuite 2024

Very easy to use with its GUI

Designed for ease of use, which means less programming and more exploring and simulations. One simple workflow to analyze in real time the effect of different treatments and model parameters on a typical individual and to simulate a population of individuals in different groups.

Amazing flexibility

Intuitive interface with an amazing flexibility to describe any scenario. In a few clicks, integrated plugins define any population, model parameters and covariates, any treatment, and any design. Simulations of clinical trials have never been so simple.

Advanced Statistical Methodologies

Built-in tools perform post-processing of simulation outputs into outcomes and endpoints. Together with statistical tests and uncertainty analysis, they provide powerful qualitative and quantitative comparison between simulation groups.

Increased productivity and quality

Working independently and integrated with Monolix – build a simulation from scratch or import a Monolix project as a starting point. Efficient C++ solver package, standardized model language, and automatic display of results in interactive tables and plots all contribute to better productivity and quality.

03. SIMULX WHAT & HOW
Novel Approaches

Optimal environment to build and analyze simulation scenarios

  • Definition – create easily new exploration and simulation elements (parameters, treatments, outputs, covariates, etc.) of different types using built-in methods or external tables
  • Exploration – analyze in real time different treatments and effects of model parameters by simulating a typical individual; create several exploration groups, overlay experimental data and send a scenario in a single click to a clinical trial simulation
  • Simulation – simulate clinical trials using a population of individuals in one or several groups with specific treatment, individual characteristics or measurement times; use flexible post-processing tools, and get immediate feedback in intuitive exportable tables and interactive plots.

Outputs and plots

All simulation outputs are displayed in sortable and formatted tables easy to copy in any document and are exported in the result folder in an R-compatible format. Interactive plots are also automatically generated for straightforward interpretation of the results.

R API to automate your process

All steps performed in Simulx can be run from R with the LixoftConnectors package. What you have done once intuitively in the interface in a specific scenario can be generalized to a script automating the process for any other simulation or design optimization.

Comprehensive documentation and examples

Great care has been taken to provide a comprehensive Simulx documentation that includes methodology, software manuals and tutorials.
A wide collection of examples that include models and data can be used as templates to start your own project.

A lot of online material (feature of the weeks videos, webinars, case studies, …) on our Lixoft University page.

Simulx has been widely used by pharmaceutical companies and academics to:

  • Make more informed decisions with reliable and extended analysis of possible scenarios.
  • Compare different dosing regimens and find the most promising ones in terms of safety and efficiency.
  • Assess the uncertainty in a clinical trial, calculate the expected power of a study, and select the most successful design.
  • Use results of one phase of a clinical trial to optimize treatment, sample size and duration of the next phase.

CHECK OUR VIDEO TUTORIALS

  

Export of all covariates from Monolix and PKanalix
  • When exporting a project from Monolix or PKanalix to Simulx, it is now possible to export unused covariates, in addition to those used in the model
  • Plots in Simulx can now be stratified using the unused covariates
Confidence interval for the study power
  • Endpoint summary table for the percentage of “successful” replicate simulations now displays a confidence interval taking into account the number of replicates
Define the [INDIVIDUAL] block in one click
  • After loading a structural model with a [LONGITUDINAL] block, it is now possible to generate the corresponding [INDIVIDUAL] block in one click.
Define regressors with a distribution
  • Regressor elements can now be defined as distributions (e.g., normal, lognormal, logitnormal, uniform)
  • When working with a sequential PD model with individual PK parameters passed as regressors, new individual PK parameters can now be sampled from this distribution.

 

 

04. SIMULX EXPERTS
Meet The Experts

How do I move forward from here?

Request for a demo with Simulx to support internal research projects and regulatory interactions.