Your #1 Ranked Team for Exposure and Safety Solutions!

Authors: Howell BA, DiBella J
Conference: SOT
Keywords: model-informed drug development, Modeling and simulations, research and development, toxicokinetics
Software: ADMET Predictor®, DILIsym®, GastroPlus®, RENAsym®
Division: PBPK, Quantitative Systems Pharmacology (QSP)

Evolving Relationship Between M&S Solutions and R&D

  • Model “supported” (first questions 20 years ago):
    • Do you think modeling and simulation might help?
  • Model “based” (questions 5 years ago):
    • How can I maximize the value of modeling and simulation in my development program?
  • Model “informed” (questions today):
    • How do I change our R&D process to reflect the availability of in silico tools and techniques?

By Brett Howell, John DiBella

Presented at SOT 61st Annual Meeting and ToxExpo March 27-31, 2022