Weight Loss and Nausea from Subcutaneous and Oral Semaglutide Accurately Simulated with a QSP Model

Authors: Kenz Z, Siler SQ, C Vallejo
Conference: ACoP
Keywords: acop2024, nausea, OBESITYsym, Oral semaglutide, QSP model, subcutaneous, weight loss

The recent availability of effective GLP-1R agonist (GLP-1RA) based treatments of obesity has provided great benefit to patients. Understanding the balance between body weight (BW) loss
and nausea is paramount in predicting the effectiveness of GLP-1RA based medications, as is potential impact of delivery method. Quantitative systems pharmacology (QSP) modeling can
aid in predicting both efficacy and adverse events of compounds, in particular assessing sources of similarities and differences between treatment protocols.