Verubecestat pharmacokinetic and exposure-response results from APECS, a phase 3 trial in prodromal alzheimer’s disease

Authors: Stone J, Kleijn H, Jaworowicz DJ, Passarell JA, Dockendorf M, Xu M, Rasmussen C, Voss T, Egan M
Conference: Alzheimers Association International Conference
Keywords: Alzheimers, APECS, BACE, exposure-response, MK-8931, verubecestat
Division: Clinical Pharmacology and Pharmacometrics (CPP)

Introduction

• The BACE inhibitor verubecestat (MK-8931) demonstrated cognitive and functional decline relative to placebo in a 2-year Phase 3 trial of individuals with prodromal AD (APECS; NCT01953601), along with reductions in brain volume and amyloid plaque. Disease progression modeling has demonstrated a lack of dose or exposure dependency in the clinical cognition and function endpoints (see Poster# P1-044)
• In this analysis, pharmacokinetic (PK), safety, and biomarker data from the trial were examined to characterize target engagement and biomarker exposure-response

The Alzheimers Association International Conference (AAIC); July 14-18, 2019; Los Angeles, CA.

By J Stone, H Kleijn, David Jaworowicz, Julie Passarell, M Dockendorf, M Xu, C Rasmussen, Rebecca Humphrey, T Voss,  M Egan.