Understanding dermal drug disposition using TCAT™ – a novel PBPK model

Skin is the major organ in the human body with a highly complex barrier that serves as protection from the external environment. Predicting dermal and systemic exposures of drug following topical application is especially challenging when considering the impact of formulations. Scientists from GlaxoSmithKline and Simulations Plus have collaborated to develop a mathematical model, Transdermal Compartmental Absorption & Transit (TCAT™), that allows better understanding of drug penetration through the skin while accounting for the formulation characteristics, evaporation and precipitation effects that influence dermal delivery. The talk entitled “Understanding dermal drug disposition using TCAT – a novel PBPK model” will focus on details of the TCAT model and what it offers.

Speakers are:
Valeriu Damian
Director – Systems Modeling and Translational Biology
GlaxoSmithKline

Anu Shilpa Krishnatry
Clinical Pharmacologist – Clinical Pharmacology Modeling and Simulation
GlaxoSmithKline