THU0549 Absence of Association Between Drug Exposure and Infection in Patients With Polyarticular-Course Juvenile Idiopathic Arthritis and Inadequate Response to Biologic or Non-Biologic DMARDS Treated With SC and IV Abatacep

Authors: Ruperto N, Brunner H, Tzaribachev N, Louw I, Calvo I, Horneff G, Henrickson M, Rama ME, Fischbach M, Miraval T, Ally MM, Li X, Wong R, Nys M, Murthy B, Lin K, Passarell JA, Martini A, Lovell DJ
Publication: Annals of the Rheumatic Diseases

Abstract

Background Infections are the most common expected AEs linked to biologic (b) DMARDs in paediatric patients (pts) with juvenile idiopathic arthritis (JIA). Blood concentrations achieved with bDMARDs vary greatly between individual pts. It is not known if higher abatacept (ABA) exposure is linked to higher infection risk in paediatric populations.

By, Ruperto N, Brunner HI, Tzaribachev N, Louw I, Calvo I, Horneff G, Henrickson M, Rama ME, Fischbach M, Miraval T, Ally MM, Li X, Wong R, Nys M, Murthy B, Lin K, Passarell JA, Martini A, Lovell DJ.