The GastroPlus® Additional Dosage Routes Seminar Series IM with Viera Lukacova

Authors: Lukacova V
Keywords: controlled-release (CR), GastroPlus Additional Dosage Routes Seminar Series, immediate release (IR) dosage form, injections, intramuscular (IM) drug delivery
Software: GastroPlus®
Division: PBPK

Abstract

The intramuscular (IM) drug delivery model represents the site of injection as a single compartment. Within this compartment, the drug can be bound, and local clearance can take place. The drug can also be transported into the lymph or systemic circulation. GastroPlus provides two intramuscular (IM) dosage forms, both of which assume that the drug is injected into the muscle tissue. One of these is an immediate release (IR) dosage form, with the other treated as controlled-release (CR).

By Viera Lukacova