Synthesis and pharmacodynamics of ibuprofen-1-acetoxyethyl ester

Authors: Wang B, Hou W, Wang Y, Li S, Liu Z, Song Z
Publication: Chem Res Chin Univ
Keywords: ADMET-risk, ibuprofen, ibuprofen-1-acetoxyethyl ester, pharmacodynamic research
Software: ADMET Predictor®

Abstract

Ibuprofen(IBU) and its derivatives are widely used in treating many diseases, such as depression, glomerulonephritis, fever caused by common cold or influenza, and rheumatoid arthritis. While in clinical trials, IBU was found to have many side effects. To weaken and prevent these side effects, a derivative called ibuprofen-1-acetoxyethyl ester was synthesized in this paper. The maximum concentration(cmax) in a shorter time was compared with IBU at the same dose.