Simulation of in vitro Dissolution and Degradation of Orntide-loaded PLGA Microspheres

Authors: Mullin JM, van Osdol W, Lukacova V, Woltosz WS, Bolger MB
Conference: CRS
Software: DDDPlus™

Introduction

An in vitro dissolution model has been developed to describe the drug release from orntide-loaded PLGA microspheres. Literature data for the degradation rates of various PLGA polymers obtained from literature were used to parameterize the in vitro dissolution
model to predict the differences in drug release from PLGA microspheres with varying lactic acid/glycolic acid (LA/GA) ratios. We then assessed the ability of the model to predict new formulations with different LA/GA ratios using published data for orntide-loaded PLGA microspheres.

Controlled Release Society Annual Meeting & Exposition, July 16-19, 2017, Boston, MA

By James Mullin, William van Osdol, Viera Lukacova, Walter S. Woltosz, Michael B. Bolger