Simulation of human intravenous and oral pharmacokinetics of 21 diverse compounds using physiologically based pharmacokinetic modelling

Authors: Jones HM, Gardner IB, Collard WT, Stanley PJ, Oxley P, Hosea NA, Plowchalk D, Gernhardt S, Lin J, Dickins M, Rahavendran SR, Jones BC, Watson KJ, Pertinez H, Kumar V, Cole S
Publication: Clin Pharmacokinet
Keywords: animals, area under curve, biological models, computer simulation, dogs, humans, injections, intravenous, metabolic clearance, oral administration, pharmaceutical preparations, pharmacokinetics, rats, species specificity
Software: GastroPlus®

Background

The importance of predicting human pharmacokinetics during compound selection has been recognized in the pharmaceutical industry. To this end there are many different approaches that are applied.