Revisiting MUT_RISK in ADMET Predictor®

Authors: Daga PR, Clark RD
Conference: SLP MIDD+
Keywords: admet predictor, chemical, discovery, DNA, mutagenicity, SLP2021MIDD
Software: ADMET Predictor®
Division: PBPK

Mutagenicity

  • A mutagen is a physical or chemical agent that changes the genetic material, usually DNA, thus increasing the frequency of mutations

OECD Guidelines TG471

A substance must be tested in a minimum of five strains with and/or without a mammalian liver homogenate preparation (S9):

  • TA98;
  • TA100;
  • TA1535
  • any one of TA1537, TA97 or TA97a
  • any one of TA102, WP2 uvrA, or WP2 uvrA pKM101

By Pankaj R. Daga & Robert D. Clark

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Presented at SLP MIDD+ Virtual Conference March 3-4, 2021