Representation of Efavirenz mediated Drug Induced Liver Injury (DILI) Using Quantitative Systems Toxicology (QST)

Authors: Longo DM, Yang K, Howell BA, Woodhead JL
Conference: ACoP
Keywords: DILI, DILIsym, efavirenz, HIV, QST modeling
Software: DILIsym®
Division: Quantitative Systems Pharmacology (QSP)

Introduction

Efavirenz is a non-nucleoside reverse transcriptase inhibitor (NNRTI) used in combination with other agents to treat human immunodeficiency virus (HIV) infection. Efavirenz  treatment is associated with a low frequency of serum enzyme elevations1. To understand the hepatotoxicity mechanisms underlying clinically observed liver signals, efavirenz was represented
in DILIsym®, a QST model of DILI.

Presented at ACoP 11 Virtual Conference, Nov. 9-13, 2020

By Diane M. Longo, Kyunghee Yang, Brett A. Howell, Jeffrey L. Woodhead