Relationships between the antidotal efficacy and structure, PK/PD parameters and bio-relevant molecular descriptors of AChE reactivating oximes: inclusion and integration to biopharmaceutical classification systems

Authors: Voicu V, Radulescu FS, Medvedovici A
Publication: Expert Opin Drug Metab Toxicol
Keywords: AChE reactivators, biodistribution, biopharmaceutical classifications, organophosphorus intoxication, oximes, pharmacokinetics
Software: ADMET Predictor®

Introduction

The therapeutic outcome of oximes used as reactivators of phosphorylated human acetylcholinesterase (AChE) is influenced, among other factors, by their biological distribution, their in vivo ability to achieve the nucleophilic attack and their affinity for the anionic center of the intact/inhibited AChE.