Quantitative Systems Toxicology Modeling Provides Novel Mechanistic Insights into Disease-related Tolvaptan Hepatotoxicity​

Authors: Watkins PB, Beaudoin J
Conference: SLP MIDD+
Keywords: ADPKD patients, Phase III, QST software, SLP MIDD+ Virtual Conference, SLP2021MIDD, Tolvaptan Hepatotoxicity, toxicology
Software: DILIsym®
Division: Quantitative Systems Pharmacology (QSP)

Paul B. Watkins, Howard Q Ferguson Distinguished Professor​, Director, Institute for Drug Safety Sciences and James Beaudoin, Scientist I present Quantitative Systems Toxicology Modeling Provides Novel Mechanistic Insights into Disease-related Tolvaptan Hepatotoxicity​.

Topics covered:

  • Incidence of Tolvaptan hepatotoxicity in ADPKD patients
  • The current concept on mechanisms underlying idiosyncratic hepatotoxicity of drugs
  • DILIsym®: QST software
  • and more!

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Presented at SLP MIDD+ Virtual Conference March 3-4, 2021