Plasma Pharmacokinetic (PK) Profile of Two Consecutive Doses of Ferumoxytol in Healthy Subjects

Authors: Pai A, Owen JS, Clarkin M, Nielsen J, Clark T, Lawler D, Kausz A
Conference: American Society of Nephrology (ASN)
Keywords: capacity-limited elimination, chronic kidney disease, hematology, iron, iron deficiency anemia, miscellaneous agents, nephrology, open model, two compartment, two-compartment model
Division: Clinical Pharmacology and Pharmacometrics (CPP)

Background

Ferumoxytol is a carbohydrate-coated superparamagnetic iron oxide nanoparticle being evaluated for safety and efficacy in two distinct areas of medical need:

  • As an iron replacement therapy in anemic patients with chronic kidney disease (CKD), both on dialysis and not on dialysis
  • As a vascular contrast agent for use with magnetic resonance imaging (MRI).

American Society of Nephrology (ASN), San Francisco, California, November 2007

By A Pai, Joel S. Owen, M Clarkin, J Nielsen, T Clark, D. Lawler, A Kausz