Pharmacokinetics of Paracetamol in Göttingen Minipigs: In Vivo Studies and Modeling to Elucidate Physiological Determinants of Absorption

Authors: Suenderhauf C, Tuffin G, Lorentsen H, Grimm HP, Flament C, Parrott N
Publication: Pharm Res
Keywords: absorption, acetaminophen, area under curve, biological availability, biological models, gastric emptying, intravenous injections, metabolism, non-narcotic analgesics, oral administration
Software: GastroPlus®

Purpose

Onset and rate of gastric emptying are important determinants of drug absorption after oral dosing. Therefore, robust estimates of these parameters are needed in physiologically based absorption models to predict reliably plasma concentration time profiles. For human and some other laboratory animals, reasonable parameterization of gastric emptying has been established. However gastric emptying is less well characterized in minipigs, a large animal model rapidly gaining importance in pharmaceutical research.