Bringing you scientific talks & poster presentations you missed from the 59th Annual SOT/Tox Expo and American Society for Clinical Pharmacology & Therapeutics conference by Simulations Plus… virtually.
Stochastic Assessment of Adaptive Volunteer Infection Study (aVIS) Designs in Malaria – A Case Study with Artefenomel
Traditional Malaria Volunteer infection studies use three consecutive single dose level cohorts (n=8).
Development and Evaluation of a Simulation Platform for Malaria Volunteer Infection Study (VIS) Designs
Traditional malaria volunteer infection studies have three consecutive single-dose cohorts.
Early assessment of PK properties with the ADMET Predictor® HTPK Simulation module, a high-throughput mechanistic PBPK approach
This webinar introduces how the ADMET Predictor® HTPK Simulation module can effectively be used to provide early PK assessment in discovery programs.
Live Stream Learning with Simulations Plus: Day One
Bringing you scientific talks & poster presentations you missed from the 59th Annual SOT/Tox Expo and American Society for Clinical Pharmacology & Therapeutics conference by Simulations Plus… virtually.
Simulations Plus Partners with Large Pharmaceutical Company to Enhance High-Throughput PBPK Capabilities in ADMET Predictor®
Updated Functionality Seamlessly Integrates Mechanistic Modeling in Drug Discovery
Modeling DILI Drug-Drug Interactions with DILIsym
DILIsym Services, Inc. offers comprehensive program services:
Clinical DILI and State-of-the-Art Solutions
Translating in vitro safety data into quantitative risk assessment in specific patient populations remains a challenge.
Simulations Plus Sets Date for 2nd Quarter 2020 Earnings Release and Conference Call
Conference Call to be on Thursday, April 9, 2020, at 4:15 PM ET
Feature of the week #84: VPC for time-to-event data
VPC of survival data is a crucial diagnostic plot in the modeling of time-to-event data
Simulations Plus Acquires Lixoft, Expanding Modeling Software Offerings and Broadening Presence in Europe
Accretive acquisition adds Monolix Suite, a population PKPD modeling solution for pharmacometricians
Translational Modeling Strategies for Orally Administered Drug Products: Academic, Industrial and Regulatory Perspectives
During non-clinical and clinical development of a new molecular entity (NME), modeling and simulation (M&S) are routinely used to predict...
Simulations Plus Sets Date for 2nd Quarter 2020 Earnings Release and Conference Call
Conference Call to be on Thursday, April 9, 2020, at 4:15 PM ET
A next generation risk assessment case study for coumarin in cosmetic products
Next Generation Risk Assessment (NGRA) is defined as an exposure-led, hypothesis-driven risk assessment approach that...
Physiologically-based pharmacokinetic models for children: Starting to reach maturation?
Developmental changes in children can affect the disposition and clinical effects of a drug, indicating that scaling an...
Alflutinib (AST2818), primarily metabolized by CYP3A4, is a potent CYP3A4 inducer
Alflutinib (AST2818) is a third-generation epidermal growth factor receptor (EGFR) inhibitor that inhibits both EGFR-sensitive mutations and T790M mutations.
Liver toxicity of anthraquinones: A combined in vitro cytotoxicity and in silico reverse dosimetry evaluation
Anthraquinones are found in a variety of consumer products such as dietary supplements, traditional Chinese medicines, and drugs.
(Q)SAR tools for the prediction of mutagenic properties: Are they ready for application in pesticide regulation?
The assessment of human health risks resulting from the presence of metabolites in groundwater and food residues has become an important element...
Feature of the week #83: Several ways to handle the baseline of PD models
The baseline of PD models can be estimated as a model parameter, fixed to the observed value or a mixture of both.