This short note discusses a few examples of pseudo DPs observed by us or by other authors.
Synthesis and Investigation on the Antidiabetic Effect of 3-aryl-1-(5-methylisoxazol-3-ylamino)-1-(4-nitrophenyl) Propan-1-one
Diabetes mellitus is the third-largest non-communicable chronic disease worldwide.
Tiered approaches for screening and prioritizing chemicals through integration of pharmacokinetics and exposure information with in vitro dose-response data
With the advent of high throughput (HT) methodologies to evaluate hazard and exposure concerns more rapidly and for a greater number of chemicals at a time, in vivo toxicity data is lacking for a large number of chemicals currently on market or in production.
NTP Research Report on Synthetic Turf/Recycled Tire Crumb Rubber: Feasibility Study in Support of Non-inhalation In Vivo Exposures of Synthetic Turf/Recycled Tire Crumb Rubber
Public health concern for playing on synthetic turf fields with crumb rubber infill has increased in recent years.
Development of a Physiologically Based Pharmacokinetic Model for Losartan and Its Active Metabolite E3174 – Ethnic Differences in Pharmacokinetics between Caucasian and Asian Populations
Losartan is a selective, competitive angiotensin II receptor type 1 (AT1) antagonist for hypertension treatment.
Physicochemical Parameters of Recently Approved Drugs
The growing importance of peptide drug within the pharmacopoeia has become evident over the past several decades.
Using Quantitative Systems Toxicology (QST): Improving the Safety of Drugs While Reducing Animal Testing
QST modeling is having a significant impact on decision making in drug development.
In Silico Study of 8-substituted-7-Methoxy-2h-Chromen-2-One Compound As Inhibitor of Telomerase Enzyme
Adjustment of telomere length by telomerase is considered as a biological marker which determine the proliferation of cancer cells.
3D-Printed Wearable Personalized Orthodontic Retainers for Sustained Release of Clonidine Hydrochloride
Orthodontic retainers are wearable customizable medical devices for dental protection or alignment.
Pharmacodynamic Effects of Sulbactam/Meropenem/Polymyxin-B Combination Against Extremely Drug Resistant Acinetobacter baumannii Using Checkerboard Information
Aim: The aims of the study are to evaluate the activity of sulbactam, meropenem, and polymyxin B alone and in combination against six isolates of extremely drug resistant...
Complementary HPLC, in silico toxicity, and molecular docking studies for investigation of the potential influences of gastric acidity and nitrite content on paracetamol safety
This study was initiated for investigating the possible gastro-transformations that may affect the integrity and safety of the most commonly administered analgesic and antipyretic, paracetamol (PCM).
Simulations Plus Enters into New Research Collaboration Agreement with the FDA
Center for Veterinary Medicine to apply GastroPlus® to assess product bioequivalence in canines
Bridging in vitro dissolution and in vivo exposure for acalabrutinib. Part I. Mechanistic modelling of drug product dissolution to derive a P-PSD for PBPK model input
Drug product dissolution for four batches of acalabrutinib 100 mg capsules were analyzed with in vitro dissolution in various pH conditions and in media containing synthetic surfactant micelles or biorelevant micelles.
Bridging in vitro dissolution and in vivo exposure for acalabrutinib. Part II. A mechanistic PBPK model for IR formulation comparison, proton pump inhibitor drug interactions, and administration with acidic juices
Acalabrutinib (Calquence®) 100 mg (bid) has received accelerated approval by FDA for the treatment of adult patients with mantle cell lymphoma (MCL) who have received at least one prior therapy.
Concepts of Artificial Intelligence for Computer-Assisted Drug Discovery
Artificial intelligence (AI), and, in particular, deep learning as a subcategory of AI, provides opportunities for the discovery and development of innovative drugs.
Simulations Plus Reports Third Quarter FY2019 Financial Results
Record quarter as revenues grow 16%, 9MoFY19 revenues up 13%
Board of Directors announces quarterly dividend of $0.06 per share
PKPlus™ 2.5 Release Webinar
Learn about the latest developments in PKPlus™
1-Methyl-1,2,3,4-tetrahydroisoquinoline – The toxicological research on an exo/endogenous amine with antidepressant-like activity – In vivo, in vitro and in silico studies
1-Methyl-1,2,3,4-tetrahydroisoquinoline (1MeTIQ) demonstrates significant neuroprotective activity.