Pramipexole is the first‐line medication recommended by the British National Institute for Health and Care Excellence.
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Physiologically Based Pharmacokinetic Modeling and Tissue Distribution Characteristics of SHetA2 in Tumor-Bearing Mice
The orally available novel small molecule SHetA2 is the lead sulfur-containing heteroarotinoid that selectively inhibits cancer cells over normal cells, and is currently under clinical development for...
Medicinal importance of Ferula asafetida oligo- gum resins against infective diseases
Ferula foetida oligo-gum resin containing phytochemicals with anti-viral properties.
Feature of the week #78: Creating a custom theme for Monolix plots
You can create one or several custom themes and apply it to all Monolix plots when appropriate, and even share...
New insights into the vancomycin‐induced nephrotoxicity using in vitro metabolomics combined with physiologically based pharmacokinetic modeling
Vancomycin is a first‐line treatment for invasive infections caused by multidrug‐resistant gram‐positive bacteria.
Multifunctional 6-fluoro-3-[3-(pyrrolidin-1-yl)propyl]-1,2-benzoxazoles targeting behavioral and psychological symptoms of dementia (BPSD)
Patients suffering from dementia experience cognitive deficits and 90% of them show non-cognitive behavioral and psychological symptoms of dementia (BPSD).
Feature of the week #77: Generating predictive checks on an external data set
Following last week’s video, this video focuses on another example of analysis that can be done by using a population model estimated...
Discovery of 9O-Substituted Palmatine Derivatives as a New Class of Anti-COL1A1 Agents Via Repressing TGF-β1/Smads and JAK1/STAT3 Pathways
Twenty 9O-substituted palmatine derivatives were prepared and tested for their biological effect against collagen...
February 2020 GastroPlus Newsletter
It is still winter and cold here in New England; however the workshop and meeting schedule is heating up!
The biorelevant simulation of gastric emptying and its impact on model drug dissolution and absorption kinetics
The highly variable physiological conditions within the gastrointestinal tract can cause variable drug release and absorption from the orally administrated dosage forms.
Efficient Pharmacokinetic Modeling Workflow With the MonolixSuite: A Case Study of Remifentanil
MonolixSuite is a software widely used for model‐based drug development.
Synthesis and biological activities of nitro‐hydroxy‐phenylquinolines; validation of antibiotics effect over DNA gyrase inhibition and antimicrobial activity
A family of 11 nitrophenol 2‐nitro‐5‐(4‐substituted phenylquinolin‐2‐yl)phenol derivatives (4, 4a‐j) was effectively...
Feature of the week #76: Calculate EBEs for a new data set using an existing model
Population parameters estimation is an obligatory task and has to run before any other task.
What does it take to develop a PBPK model that mimics in vivo behavior of LAIs? Part II
This presentation will take a closer look at possible mechanisms affecting behavior of suspensions of low solubility drugs.
In Silico Strategies in Tuberculosis Drug Discovery
Tuberculosis (TB) remains a serious threat to global public health, responsible for an estimated 1.5 million mortalities in 2018.
Pharmacokinetics and pharmacodynamics of three oral formulations of curcumin in rats
Curcumin (CUR) is a major component of turmeric Curcuma longa, which is often used in food or as a dietary supplement.
DILIsym Services Partners with Large Pharmaceutical Company to Begin QSP Model Development for Heart Failure
QSP Modeling Project Targeted at Prevention of Heart Failure
Gender effect on the pharmacokinetics of thymoquinone: Preclinical investigation and in silico modeling in male and female rats
Thymoquinone is the most biologically active constituent of Nigella sativa (black seed).