There has been an increasing desire to incorporate mechanistic models of in vitro experiments to evaluate the interplay between...
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Synthesis and Characterization of 9-(4-[18F]Fluoro-3-(hydroxymethyl)butyl)-2-(phenylthio)-6-oxopurine as a Novel PET Agent for Mutant Herpes Simplex Virus Type 1 Thymidine Kinase Reporter Gene Imaging
[18F]FHBG has been used as a positron emission tomography (PET) imaging tracer for the monitoring of herpes simplex virus type 1 thymidine kinase...
Teaching of Biopharmaceutics in a Drug Design Course: Use of GastroPlus as Educational Software
Drug design and development requires collaboration among scientists with diverse expertise.
Modeling of ayurveda ghee based solid lipid nano particles and their comprehensive pharmacokinetics study
Several experiments have been done with solid lipid nanoparticles (SLNPs) module to produce a potential oral drug delivery system.
Food Effects on Oral Drug Absorption: Application of Physiologically-Based Pharmacokinetic Modeling as a Predictive Tool
The bioavailability of an orally administered small molecule is often dictated by drug-specific...
Holistic Prediction of the pKa in Diverse Solvents Based on a Machine‐Learning Approach
While many approaches to predict aqueous pKa values exist, the fast and accurate prediction of non‐aqueous pKa values is still challenging.
Pentabromobenzyl-RP versus triazole-HILIC columns for separation of the polar basic analytes famotidine and famotidone: LC method development combined with in silico tools to follow the potential consequences of famotidine gastric instability
The competence of hydrophilic interaction (HILIC) and reversed phase liquid chromatography (RPLC) modes, employing two new stationary phases...
Global testing of a consensus solubility assessment to enhance robustness of the WHO biopharmaceutical classification system
The WHO Biopharmaceutical Classification System (BCS) is a practical tool to identify active pharmaceutical ingredients (APIs) that scientifically qualify for...
Feature of the week #94: Individual parameters
Monolix estimates the population parameters, which characterize the population. But often we also need the parameter values for each individual present in the dataset.
Simulations Plus Reports Third Quarter FY2020 Financial Results
Third Quarter and 9MoFY20 Revenues Grow 24%
Review of the pharmacokinetics and metabolism of triclopyr herbicide in mammals: Impact on safety assessments
A review of pharmacokinetic and metabolism studies show that triclopyr is well absorbed from the oral route in numerous species...
The art of atom descriptor design
This review provides an overview of descriptions of atoms applied to the understanding of phenomena like chemical reactivity and selectivity...
Simulations Plus Sets Date for 3rd Quarter 2020 Earnings Release and Conference Call
Conference Call to be on Thursday, July 9, 2020, at 4:15 PM ET
Estimation of Attainment of Steady‐State Conditions for Compounds With a Long Half‐Life
Half‐life is a standard result reported with analysis of pharmacokinetic data.
Feature of the week #93: Initial integration time
When a model is defined as a system of differential equations, the initial integration time corresponding to the initial conditions of the system is not necessarily 0.
Phytocannabinoid drug-drug interactions and their clinical implications
Cannabis is a plant with a long history of human pharmacological use, both for recreational purposes and as a medicinal remedy.
Policy of Multisource Drug Products in Latin America: Opportunities and Challenges on the Application of Bioequivalence In Vitro Assays
Background: The replacement of traditional in vivo bioequivalence studies by in vitro dissolution assays, based on the biopharmaceutical classification system (BCS), has...
Pediatric dose selection for fremanezumab (AJOVY) phase 3 migraine study using pharmacokinetic data from a pediatric phase 1 study and a population pharmacokinetic modeling and simulation approach
Previous examination of the relationship between fremanezumab exposures and baseline body weight supports a weight cutoff of 45 kg of pediatric dose selection, with the approved adult dose of 225 mg monthly being appropriate or patients weighing >= 45 kg