This video is dedicated to support files and how to load your data in GastroPlus.
GastroPlus® Tutorial: Phase 1: Video 2: How to start a PBBM PBPK project in GastroPlus
In this video we'll show you how to start a project with GastroPlus.
Decomposition profile data analysis of multiple drug effects identifies endoplasmic reticulum stress-inducing ability as an unrecognized factor
Chemicals have multiple effects in biological systems.
Chemical space and diversity of seaweed metabolite database (SWMD): A cheminformatics study
Seaweeds have attracted attention in the past decade as a biological source of highly diverse secondary metabolites with great potential in the...
Simulations Plus Announces Proposed Underwritten Public Offering
Simulations Plus, Inc. (Nasdaq: SLP), a premier developer of drug discovery and development software for modeling and simulation software products and...
Exploring QSAR models for assessment of acute fish toxicity of environmental transformation products of pesticides (ETPPs)
Environmental transformation products of pesticides (ETPPs) have a great deal of ecological impact owing to their ability to cause toxicity to the...
Fatty acid profile and in silico pharmacological study of diatom Amphora sp
Amphora sp. is a type of potential microalgae that has a considerably high content of lipid.
Effect of Fremanezumab Monthly and Quarterly Doses on Efficacy Responses
Exposure-response (E-R) models were developed to provide a description of the time-course of treatment effect for monthly and quarterly dosing regimens of...
How To Improve Your Compound Design & Screening Using ADMET Property Prediction and PK Simulations Day 2
Simulations Plus, in partnerships with pharmaceutical companies globally, has made significant investments in its ADMET Predictor® platform to implement...
GastroPlus® Tutorial: Phase 1: Prediction of plasma concentration
The goal is to predict the plasma concentration time following intravenous administration using a compartmental model.
How To Improve Your Compound Design & Screening Using ADMET Property Prediction and PK Simulations Day 1
Simulations Plus, in partnerships with pharmaceutical companies globally, has made significant investments in its ADMET Predictor® platform to implement...
Effect of the structural factors of organic compounds on the acute toxicity toward Daphnia magna
The acute toxicity of organic compounds towards Daphina magna was subjected to QSAR analysis.
Molecular engineering of safe and efficacious oral basal insulin
Recently, the clinical proof of concept for the first ultra-long oral insulin was reported, showing efficacy and safety similar to subcutaneously administered insulin glargine. Here, we report the molecular engineering as well as biological and pharmacological properties of these insulin analogues.
The good, the bad, and the ugly in chemical and biological data for machine learning
Machine learning and artificial intelligence (ML/AI) have become important research tools in molecular medicine and chemistry.
Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of the Anti‐CD38 Cytolytic Antibody TAK‐079 in Healthy Subjects
This investigation characterised tolerability, pharmacokinetics and pharmacodynamics of the
High-quality, User-friendly PK Data Analysis with PKPlus™
As more compounds are screened in animal studies, simplified PK/TK data analyses and modeling & simulation routines.
Simulation of Physicochemical and Pharmacokinetic Properties of Vitamin D3 and Its Natural Derivatives
Vitamin D3 is an endogenous fat-soluble secosteroid, either biosynthesized in human skin or absorbed from diet and health supplements.
Simulation of Physicochemical and Pharmacokinetic Properties of Vitamin D 3 and Its Natural Derivatives
Vitamin D3 is an endogenous fat-soluble secosteroid, either biosynthesized in human skin or absorbed from diet and health supplements.
Modeling in vitro Permeability with MembranePlus™
The chase is on to improve IVIVE approaches for compounds which are subject to complex absorption and clearance processes.