The competence of hydrophilic interaction (HILIC) and reversed phase liquid chromatography (RPLC) modes, employing two new stationary phases...
Global testing of a consensus solubility assessment to enhance robustness of the WHO biopharmaceutical classification system
The WHO Biopharmaceutical Classification System (BCS) is a practical tool to identify active pharmaceutical ingredients (APIs) that scientifically qualify for...
Feature of the week #94: Individual parameters
Monolix estimates the population parameters, which characterize the population. But often we also need the parameter values for each individual present in the dataset.
Simulations Plus Reports Third Quarter FY2020 Financial Results
Third Quarter and 9MoFY20 Revenues Grow 24%
Review of the pharmacokinetics and metabolism of triclopyr herbicide in mammals: Impact on safety assessments
A review of pharmacokinetic and metabolism studies show that triclopyr is well absorbed from the oral route in numerous species...
The art of atom descriptor design
This review provides an overview of descriptions of atoms applied to the understanding of phenomena like chemical reactivity and selectivity...
Simulations Plus Sets Date for 3rd Quarter 2020 Earnings Release and Conference Call
Conference Call to be on Thursday, July 9, 2020, at 4:15 PM ET
Estimation of Attainment of Steady‐State Conditions for Compounds With a Long Half‐Life
Half‐life is a standard result reported with analysis of pharmacokinetic data.
Feature of the week #93: Initial integration time
When a model is defined as a system of differential equations, the initial integration time corresponding to the initial conditions of the system is not necessarily 0.
Phytocannabinoid drug-drug interactions and their clinical implications
Cannabis is a plant with a long history of human pharmacological use, both for recreational purposes and as a medicinal remedy.
Policy of Multisource Drug Products in Latin America: Opportunities and Challenges on the Application of Bioequivalence In Vitro Assays
Background: The replacement of traditional in vivo bioequivalence studies by in vitro dissolution assays, based on the biopharmaceutical classification system (BCS), has...
Pediatric dose selection for fremanezumab (AJOVY) phase 3 migraine study using pharmacokinetic data from a pediatric phase 1 study and a population pharmacokinetic modeling and simulation approach
Previous examination of the relationship between fremanezumab exposures and baseline body weight supports a weight cutoff of 45 kg of pediatric dose selection, with the approved adult dose of 225 mg monthly being appropriate or patients weighing >= 45 kg
Biopharmaceutical characterization of rebamipide: The role of mucus binding in regional-dependent intestinal permeability
In this study, we aimed to elucidate biopharmaceutical characteristics of the anti-ulcer drug rebamipide, with special emphasis on the...
Computational Methods Used in Phytocompound-Based Drug Discovery
Phytocompounds are gaining popularity, due to lesser toxicity, greater bioavailability and high chemodiversity.
In silico models for genotoxicity and drug regulation
Whereas in the past, (Q)SAR methods have been largely used to support the design of new drugs, in the last few decades...
Application of synthetic membranes in establishing bio-predictive IVPT for testosterone transdermal gel
The current study investigated the use of synthetic membranes in developing a bio-predictive in vitro permeation testing (IVPT) method for 1.62% testosterone gel.
Evaluation of the effect of synthetic compounds derived from azidothymidine on MDA-MB-231 type breast cancer cells
The present study aimed to investigate the effect of AZT derivates containing tellurium (Te) on human breast cancer cell lines and the mechanisms...
Mechanistic Investigations Support Liver Safety of Ubrogepant
Small-molecule calcitonin gene–related peptide (CGRP) receptor antagonists have demonstrated therapeutic potential for the treatment of migraine.