Simulations Plus today announced the addition of Sandra Suarez-Sharp as Vice President, Regulatory Affairs to lead the new Regulatory Strategies team.
20-year FDA Master Reviewer will advise the planning of drug development programs with sponsor companies
Physiologically based pharmacokinetic modeling (PBPK) is a valuable tool to evaluate inhalation exposure of volatile organic compounds (VOCs).
Acetaminophen has a long history of safe use at therapeutic doses, but can cause liver injury at very high doses.
PF-04895162 (ICA-105665), a drug in development for the treatment of epilepsy, was terminated after transaminase elevations (up to grade...
Cisplatin-induced nephrotoxicity results in acute kidney injury (AKI) and is caused by various cellular mechanisms, including...
Activation of AhR can have toxic effects on mammalian hosts
‘Deep learning’ is causing rapid technological changes in many fields of science, and conjectures about its potential for...
Delayed differential equations (DDEs) can be implemented in Mlxtran language using the "delay" function.
In vitro – in vivo correlation (IVIVC) allows prediction of the in vivo performance of a pharmaceutical product based on its in vitro...
Emerging drug resistance and high-attrition rates in early and late stage drug development necessitate accelerated development of antimalarial compounds.
Since last month’s newsletter, the world has become Coronavirus conscious.
Poorly soluble weak bases form a significant proportion of the drugs available in the market thereby making it imperative to...
Imidazoline I2 receptors (I2-IR), widely distributed in the CNS and altered in patients that suffer from neurodegenerative disorders ...
Throughout the drug discovery process, companies need to eliminate poor drug candidates early to avoid costly studies and dead ends.
Maxime LeMerdy introduces GastroPlus 9.7 interface and walks you through each tab.
Monolix is able to use the individual parameters of the current run to pre-test several covariate, correlation and error models
Acid-reducing agents (ARA) such as antacids, histamine H2-receptor antagonists, and proton pump inhibitors are widely prescribed in several disease states.
Oseltamivir is a neuraminidase inhibitor widely used to treat and prevent influenza A and B infections, although its safety and pharmacokinetics have not been evaluated in patients with severe hepatic impairment.
Methionine Aminopeptidases MetAPs are divalent-cofactor dependent enzymes that are responsible for the cleavage of the initiator...
