Updated Functionality Seamlessly Integrates Mechanistic Modeling in Drug Discovery
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Modeling DILI Drug-Drug Interactions with DILIsym
DILIsym Services, Inc. offers comprehensive program services:
![Clinical DILI and State-of-the-Art Solutions](https://www.simulations-plus.com/wp-content/themes/simulations-plus/library/dist/img/default_square-large.jpg)
Clinical DILI and State-of-the-Art Solutions
Translating in vitro safety data into quantitative risk assessment in specific patient populations remains a challenge.
![Simulations Plus Sets Date for 2nd Quarter 2020 Earnings Release and Conference Call](https://www.simulations-plus.com/wp-content/themes/simulations-plus/library/dist/img/default_square-large.jpg)
Simulations Plus Sets Date for 2nd Quarter 2020 Earnings Release and Conference Call
Conference Call to be on Thursday, April 9, 2020, at 4:15 PM ET
![Feature of the week #84: VPC for time-to-event data](https://www.simulations-plus.com/wp-content/themes/simulations-plus/library/dist/img/default_square-large.jpg)
Feature of the week #84: VPC for time-to-event data
VPC of survival data is a crucial diagnostic plot in the modeling of time-to-event data
![Simulations Plus Acquires Lixoft, Expanding Modeling Software Offerings and Broadening Presence in Europe](https://www.simulations-plus.com/wp-content/themes/simulations-plus/library/dist/img/default_square-large.jpg)
Simulations Plus Acquires Lixoft, Expanding Modeling Software Offerings and Broadening Presence in Europe
Accretive acquisition adds Monolix Suite, a population PKPD modeling solution for pharmacometricians
![Translational Modeling Strategies for Orally Administered Drug Products: Academic, Industrial and Regulatory Perspectives](https://www.simulations-plus.com/wp-content/themes/simulations-plus/library/dist/img/default_square-large.jpg)
Translational Modeling Strategies for Orally Administered Drug Products: Academic, Industrial and Regulatory Perspectives
During non-clinical and clinical development of a new molecular entity (NME), modeling and simulation (M&S) are routinely used to predict...
![Simulations Plus Sets Date for 2nd Quarter 2020 Earnings Release and Conference Call](https://www.simulations-plus.com/wp-content/themes/simulations-plus/library/dist/img/default_square-large.jpg)
Simulations Plus Sets Date for 2nd Quarter 2020 Earnings Release and Conference Call
Conference Call to be on Thursday, April 9, 2020, at 4:15 PM ET
![A next generation risk assessment case study for coumarin in cosmetic products](https://www.simulations-plus.com/wp-content/themes/simulations-plus/library/dist/img/default_square-large.jpg)
A next generation risk assessment case study for coumarin in cosmetic products
Next Generation Risk Assessment (NGRA) is defined as an exposure-led, hypothesis-driven risk assessment approach that...
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Physiologically-based pharmacokinetic models for children: Starting to reach maturation?
Developmental changes in children can affect the disposition and clinical effects of a drug, indicating that scaling an...
![Alflutinib (AST2818), primarily metabolized by CYP3A4, is a potent CYP3A4 inducer](https://www.simulations-plus.com/wp-content/themes/simulations-plus/library/dist/img/default_square-large.jpg)
Alflutinib (AST2818), primarily metabolized by CYP3A4, is a potent CYP3A4 inducer
Alflutinib (AST2818) is a third-generation epidermal growth factor receptor (EGFR) inhibitor that inhibits both EGFR-sensitive mutations and T790M mutations.
![Liver toxicity of anthraquinones: A combined in vitro cytotoxicity and in silico reverse dosimetry evaluation](https://www.simulations-plus.com/wp-content/themes/simulations-plus/library/dist/img/default_square-large.jpg)
Liver toxicity of anthraquinones: A combined in vitro cytotoxicity and in silico reverse dosimetry evaluation
Anthraquinones are found in a variety of consumer products such as dietary supplements, traditional Chinese medicines, and drugs.
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(Q)SAR tools for the prediction of mutagenic properties: Are they ready for application in pesticide regulation?
The assessment of human health risks resulting from the presence of metabolites in groundwater and food residues has become an important element...
![Feature of the week #83: Several ways to handle the baseline of PD models](https://www.simulations-plus.com/wp-content/themes/simulations-plus/library/dist/img/default_square-large.jpg)
Feature of the week #83: Several ways to handle the baseline of PD models
The baseline of PD models can be estimated as a model parameter, fixed to the observed value or a mixture of both.
![Simulations Plus Offers Rapid Response COVID-19 Research Initiative](https://www.simulations-plus.com/wp-content/themes/simulations-plus/library/dist/img/default_square-large.jpg)
Simulations Plus Offers Rapid Response COVID-19 Research Initiative
New StrategiesPlus™ program created for collaborative research acceleration
![Physiologically Based Biopharmaceutics Modeling and Virtual Bioequivalence Assessment to Support Formulation Development](https://www.simulations-plus.com/wp-content/themes/simulations-plus/library/dist/img/default_square-large.jpg)
Physiologically Based Biopharmaceutics Modeling and Virtual Bioequivalence Assessment to Support Formulation Development
Mechanistic Absorption and PK modeling using GastroPlus®
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In vitro evaluation of reactive nature of E- and Z-guggulsterones and their metabolites in human liver microsomes using UHPLC-Orbitrap mass spectrometer
Guggulipid is known to be useful for hypercholesterolemia, arthritis, acne, and obesity.
![Forced degradation studies of norepinephrine and epinephrine from dental anesthetics: Development of stability‐indicating HPLC method and in silico toxicity evaluation](https://www.simulations-plus.com/wp-content/themes/simulations-plus/library/dist/img/default_square-large.jpg)
Forced degradation studies of norepinephrine and epinephrine from dental anesthetics: Development of stability‐indicating HPLC method and in silico toxicity evaluation
Injectable solutions containing epinephrine (EPI) and norepinephrine (NE) are not stable, and their degradation is...
![Feature of the week #82: Kaplan-Meier estimator](https://www.simulations-plus.com/wp-content/themes/simulations-plus/library/dist/img/default_square-large.jpg)
Feature of the week #82: Kaplan-Meier estimator
Have you ever wondered how the survival function is estimated from time-to-event data?