Selection of appropriate fit-for-purpose in vitro and in silico models is critical for non-animal safety assessment of chemical-induced hepatoxicity.
![Quantitative structure–toxicity relationships in translational toxicology](https://www.simulations-plus.com/wp-content/themes/simulations-plus/library/dist/img/default_square-large.jpg)
Quantitative structure–toxicity relationships in translational toxicology
During the past decade, quantitative structure–activity relationship (QSAR) enjoyed an ever-increasing application in various fields including...
![Population Pharmacokinetic Analysis of the Cathepsin K Inhibitor Odanacatib: Insights Into Intrinsic and Extrinsic Factor Effects on Exposure in Postmenopausal and Elderly Women](https://www.simulations-plus.com/wp-content/themes/simulations-plus/library/dist/img/default_square-large.jpg)
Population Pharmacokinetic Analysis of the Cathepsin K Inhibitor Odanacatib: Insights Into Intrinsic and Extrinsic Factor Effects on Exposure in Postmenopausal and Elderly Women
This analysis developed a population pharmacokinetic (PK) model for odanacatib, characterized demographic and concomitant medication covariates effect...
![GastroPlus® “Workshop from Home” April 17 PBPK PD modeling course with Haiying Zhou](https://www.simulations-plus.com/wp-content/themes/simulations-plus/library/dist/img/default_square-large.jpg)
GastroPlus® “Workshop from Home” April 17 PBPK PD modeling course with Haiying Zhou
Advanced GastroPlus® DMPK & Clinical Pharmacology
![GastroPlus® “Workshop from Home” April 16 Transporters in PBPK modeling with Ke Szeto](https://www.simulations-plus.com/wp-content/themes/simulations-plus/library/dist/img/default_square-large.jpg)
GastroPlus® “Workshop from Home” April 16 Transporters in PBPK modeling with Ke Szeto
Advanced GastroPlus® DMPK & Clinical Pharmacology
![Studies on effects of umbelliferon derivatives against periodontal bacteria; antibiofilm, inhibition of quorum sensing and molecular docking analysis](https://www.simulations-plus.com/wp-content/themes/simulations-plus/library/dist/img/default_square-large.jpg)
Studies on effects of umbelliferon derivatives against periodontal bacteria; antibiofilm, inhibition of quorum sensing and molecular docking analysis
Umbelliferon derivatives are exclusively found in plants of Ferula spp. that are commonly used in curing various health concerns related...
![GastroPlus® “Workshop from Home” April 15 DDI predictions with John DiBella](https://www.simulations-plus.com/wp-content/themes/simulations-plus/library/dist/img/default_square-large.jpg)
GastroPlus® “Workshop from Home” April 15 DDI predictions with John DiBella
Advanced GastroPlus® DMPK & Clinical Pharmacology
![Computational studies of a series of 2-substituted phenyl-2-oxo-, 2-hydroxyl- and 2-acylloxyethylsulfonamides as potent anti-fungal agents](https://www.simulations-plus.com/wp-content/themes/simulations-plus/library/dist/img/default_square-large.jpg)
Computational studies of a series of 2-substituted phenyl-2-oxo-, 2-hydroxyl- and 2-acylloxyethylsulfonamides as potent anti-fungal agents
Botrytis Cinerea is a plant pathogen that affect a large number of plant species like tomatoes, Lettuce, Grapes, and Strawberries among others...
![GastroPlus® “Workshop from Home” April 14 Special population predictions with Viera Lukacova](https://www.simulations-plus.com/wp-content/themes/simulations-plus/library/dist/img/default_square-large.jpg)
GastroPlus® “Workshop from Home” April 14 Special population predictions with Viera Lukacova
Advanced GastroPlus® DMPK & Clinical Pharmacology
![Fundamental aspects of DMPK optimization of targeted protein degraders](https://www.simulations-plus.com/wp-content/themes/simulations-plus/library/dist/img/default_square-large.jpg)
Fundamental aspects of DMPK optimization of targeted protein degraders
Targeted protein degraders are an emerging modality.
![GastroPlus® “Workshop from Home” April 13 GastroPlus® Introduction with Maxime Le Merdy](https://www.simulations-plus.com/wp-content/themes/simulations-plus/library/dist/img/default_square-large.jpg)
GastroPlus® “Workshop from Home” April 13 GastroPlus® Introduction with Maxime Le Merdy
Introductory GastroPlus® Simulation and Modeling
![Establishment of a clinically relevant specification for dissolution testing using physiologically based pharmacokinetic (PBPK) modeling approaches](https://www.simulations-plus.com/wp-content/themes/simulations-plus/library/dist/img/default_square-large.jpg)
Establishment of a clinically relevant specification for dissolution testing using physiologically based pharmacokinetic (PBPK) modeling approaches
This paper presented how to establish a clinically relevant specification (CRS) using in silico physiologically based pharmacokinetic (PBPK) modeling.
![Feature of the week #85: Modeling exposure-response curves](https://www.simulations-plus.com/wp-content/themes/simulations-plus/library/dist/img/default_square-large.jpg)
Feature of the week #85: Modeling exposure-response curves
Exposure-response curves give the response to a drug as a function of exposure, which can be the dose or a measure of drug...
![Simulations Plus Reports Record Second Quarter FY2020 Revenue](https://www.simulations-plus.com/wp-content/themes/simulations-plus/library/dist/img/default_square-large.jpg)
Simulations Plus Reports Record Second Quarter FY2020 Revenue
Quarterly Revenues Up 22%; Board of Directors Announces Quarterly Dividend of $0.06 Per Share
![Live Stream Learning with Simulations Plus Day Two](https://www.simulations-plus.com/wp-content/themes/simulations-plus/library/dist/img/default_square-large.jpg)
Live Stream Learning with Simulations Plus Day Two
Bringing you scientific talks & poster presentations you missed from the 59th Annual SOT/Tox Expo and American Society for Clinical Pharmacology & Therapeutics conference by Simulations Plus… virtually.
![Stochastic Assessment of Adaptive Volunteer Infection Study (aVIS) Designs in Malaria – A Case Study with Artefenomel](https://www.simulations-plus.com/wp-content/themes/simulations-plus/library/dist/img/default_square-large.jpg)
Stochastic Assessment of Adaptive Volunteer Infection Study (aVIS) Designs in Malaria – A Case Study with Artefenomel
Traditional Malaria Volunteer infection studies use three consecutive single dose level cohorts (n=8).
![Development and Evaluation of a Simulation Platform for Malaria Volunteer Infection Study (VIS) Designs](https://www.simulations-plus.com/wp-content/themes/simulations-plus/library/dist/img/default_square-large.jpg)
Development and Evaluation of a Simulation Platform for Malaria Volunteer Infection Study (VIS) Designs
Traditional malaria volunteer infection studies have three consecutive single-dose cohorts.
![Early assessment of PK properties with the ADMET Predictor® HTPK Simulation module, a high-throughput mechanistic PBPK approach](https://www.simulations-plus.com/wp-content/themes/simulations-plus/library/dist/img/default_square-large.jpg)
Early assessment of PK properties with the ADMET Predictor® HTPK Simulation module, a high-throughput mechanistic PBPK approach
This webinar introduces how the ADMET Predictor® HTPK Simulation module can effectively be used to provide early PK assessment in discovery programs.
![Live Stream Learning with Simulations Plus: Day One](https://www.simulations-plus.com/wp-content/themes/simulations-plus/library/dist/img/default_square-large.jpg)
Live Stream Learning with Simulations Plus: Day One
Bringing you scientific talks & poster presentations you missed from the 59th Annual SOT/Tox Expo and American Society for Clinical Pharmacology & Therapeutics conference by Simulations Plus… virtually.