If you are like me, the static virtual meeting thing is very getting old.

Simulations Plus Sets Date for 4th Quarter and Fiscal Year 2020 Earnings Release and Conference Call
Conference Call to be on Monday, November 16, 2020, at 4:15 PM ET

Mechanisms of QT prolongation by buprenorphine cannot be explained by direct hERG channel block
Buprenorphine is a μ-opioid receptor (MOR) partial agonist used to manage pain and addiction.

Artificial intelligence and automation in computer aided synthesis planning
In this perspective we deal with questions pertaining to the development of synthesis planning technologies over the course of recent years.

Cognigen’s Global Presence
Darcy J. Hitchcock, Christian Hove (Rasmussen) Claussen, and Lindsay Lehmann introduce themselves as our global pharmacometric leaders of Cognigen.

Hepatotoxicity of Compound V Evaluated with Quantitative Systems Toxicology
Compound V is a small molecule with potential therapeutic benefits in patients with obesity.

In Vitro and In Silico ADME-Tox Profiling and Safety Significance of Multifunctional Monoamine Oxidase Inhibitors Targeting Neurodegenerative Diseases
Herein we report in vitro metabolic stability in human liver microsomes (HLMs), interactions with cytochrome P450...

Liquid Biopsy Enables Quantification of the Abundance and Interindividual Variability of Hepatic Enzymes and Transporters
Variability in individual capacity for hepatic elimination of therapeutic drugs is well recognized and is associated with variable expression and activity...

Applications of Physiologically Based Biopharmaceutics Modeling (PBBM) to Support Drug Product Quality: A Workshop Summary Report
This report summarizes the proceedings for Day 3 of the workshop titled “ Current State and Future Expectations of Translational Modeling Strategies...

Integrated network pharmacology and molecular docking approaches to reveal the synergistic mechanism of multiple components in Venenum Bufonis for ameliorating heart failure
Venenum Bufonis (VB), also called Chan Su in China, has been extensively used as a traditional Chinese medicine (TCM) for treating...

Evaluation of quantitative structure property relationship algorithms for predicting plasma protein binding in humans
The extent of plasma protein binding is an important compound-specific property that influences a compound’s pharmacokinetic behavior and ...

Negative Food Effect of Danirixin: Use of PBPK Modelling to Explore the Effect of Formulation and Meal Type on Clinical PK
To use physiologically-based pharmacokinetic (PBPK) modelling to explore the food effect of different DNX hydrobromide (HBr) hemihydrate salt tablet...

Quantitative Systems Toxicology (QST) Modeling of Drug-Induced Liver Injury and Adaptation
This talk will present how quantitative systems toxicology (QST) modeling can aid in evaluating potential drug-drug interactions.

Synthesis of 1,2,3-Triazole Benzophenone Derivatives and Evaluation of in vitro Sun Protection, Antioxidant Properties, and Antiproliferative Activity on HT-144 Melanoma Cells
Benzophenones display several biological activities, including antioxidant, anticancer, and photoprotective.

First Approved Cancer Treatment for TGCT Included DILIsym Simulations in FDA Review
FDA Review Cites DILIsym Results as Part of Turalio® Submission

Evaluation of models for predicting pediatric fraction unbound in plasma for human health risk assessment
Pediatric physiologically based pharmacokinetic (PBPK) models facilitate the prediction of PK parameters in children under specific exposure conditions.

Liothyronine could block the programmed death-ligand 1 (PDL1) activity: an e-Pharmacophore modeling and virtual screening study
The interaction between PD-L1 on tumor cells and the programmed death 1 (PD1) on immune cells helps them to escape the immune system elimination.