Sildenafil is a potent selective inhibitor of phosphosdiesterase-5 previously used in erectile dysfunction and subsequently approved in 2005 for pulmonary...
![Using a Physiologically Based Pharmacokinetic Absorption Model to Establish Dissolution Bioequivalence Safe Space for Oseltamivir in Adult and Pediatric Populations](https://www.simulations-plus.com/wp-content/themes/simulations-plus/library/dist/img/default_square-large.jpg)
Using a Physiologically Based Pharmacokinetic Absorption Model to Establish Dissolution Bioequivalence Safe Space for Oseltamivir in Adult and Pediatric Populations
Bioequivalence (BE) studies support the approval and clinical use of both new drug and generic drug products.
![Current status and future opportunities for incorporation of dissolution data in PBPK modeling for pharmaceutical development and regulatory applications: OrBiTo consortium commentary](https://www.simulations-plus.com/wp-content/themes/simulations-plus/library/dist/img/default_square-large.jpg)
Current status and future opportunities for incorporation of dissolution data in PBPK modeling for pharmaceutical development and regulatory applications: OrBiTo consortium commentary
In vitro dissolution experiments are used to qualitatively assess the impact of formulation composition and process changes on the drug dosage form performance.
![In silico Methods for Drug Design and Discovery](https://www.simulations-plus.com/wp-content/themes/simulations-plus/library/dist/img/default_square-large.jpg)
In silico Methods for Drug Design and Discovery
Computer-aided drug design (CADD) methodologies are playing an ever-increasing role in drug discovery that are critical in the cost-effective...
![Simulations Plus Announces Pricing of $100 Million Underwritten Offering of Common Stock](https://www.simulations-plus.com/wp-content/themes/simulations-plus/library/dist/img/default_square-large.jpg)
Simulations Plus Announces Pricing of $100 Million Underwritten Offering of Common Stock
Simulations Plus, Inc. (Nasdaq: SLP), a premier developer of drug discovery and development software for modeling and simulation software products...
![Identification and characterization of novel metabolites of nintedanib by ultra‐performance liquid chromatography/quadrupole time‐of‐flight tandem mass spectrometry with in silico toxicological assessment](https://www.simulations-plus.com/wp-content/themes/simulations-plus/library/dist/img/default_square-large.jpg)
Identification and characterization of novel metabolites of nintedanib by ultra‐performance liquid chromatography/quadrupole time‐of‐flight tandem mass spectrometry with in silico toxicological assessment
Nintedanib, an oral, triple angiokinase inhibitor, is used alongside docetaxel in the management of locally recurrent non‐small‐cell lung cancer...
![Forced degradation studies of medroxyprogesterone acetate injectable suspensions (150 mg/ml) with implementation of HPLC, mass spectrometry, and QSAR techniques](https://www.simulations-plus.com/wp-content/themes/simulations-plus/library/dist/img/default_square-large.jpg)
Forced degradation studies of medroxyprogesterone acetate injectable suspensions (150 mg/ml) with implementation of HPLC, mass spectrometry, and QSAR techniques
Medroxyprogesterone acetate (MPA) injectable products are a key commodity for reproductive health and are available in the global...
![GastroPlus® Tutorial: Phase 1: Video 3: Support files and loading your data into GastroPlus](https://www.simulations-plus.com/wp-content/themes/simulations-plus/library/dist/img/default_square-large.jpg)
GastroPlus® Tutorial: Phase 1: Video 3: Support files and loading your data into GastroPlus
This video is dedicated to support files and how to load your data in GastroPlus.
![GastroPlus® Tutorial: Phase 1: Video 2: How to start a PBBM PBPK project in GastroPlus](https://www.simulations-plus.com/wp-content/themes/simulations-plus/library/dist/img/default_square-large.jpg)
GastroPlus® Tutorial: Phase 1: Video 2: How to start a PBBM PBPK project in GastroPlus
In this video we'll show you how to start a project with GastroPlus.
![Decomposition profile data analysis of multiple drug effects identifies endoplasmic reticulum stress-inducing ability as an unrecognized factor](https://www.simulations-plus.com/wp-content/themes/simulations-plus/library/dist/img/default_square-large.jpg)
Decomposition profile data analysis of multiple drug effects identifies endoplasmic reticulum stress-inducing ability as an unrecognized factor
Chemicals have multiple effects in biological systems.
![Chemical space and diversity of seaweed metabolite database (SWMD): A cheminformatics study](https://www.simulations-plus.com/wp-content/themes/simulations-plus/library/dist/img/default_square-large.jpg)
Chemical space and diversity of seaweed metabolite database (SWMD): A cheminformatics study
Seaweeds have attracted attention in the past decade as a biological source of highly diverse secondary metabolites with great potential in the...
![Simulations Plus Announces Proposed Underwritten Public Offering](https://www.simulations-plus.com/wp-content/themes/simulations-plus/library/dist/img/default_square-large.jpg)
Simulations Plus Announces Proposed Underwritten Public Offering
Simulations Plus, Inc. (Nasdaq: SLP), a premier developer of drug discovery and development software for modeling and simulation software products and...
![Exploring QSAR models for assessment of acute fish toxicity of environmental transformation products of pesticides (ETPPs)](https://www.simulations-plus.com/wp-content/themes/simulations-plus/library/dist/img/default_square-large.jpg)
Exploring QSAR models for assessment of acute fish toxicity of environmental transformation products of pesticides (ETPPs)
Environmental transformation products of pesticides (ETPPs) have a great deal of ecological impact owing to their ability to cause toxicity to the...
![Fatty acid profile and in silico pharmacological study of diatom Amphora sp](https://www.simulations-plus.com/wp-content/themes/simulations-plus/library/dist/img/default_square-large.jpg)
Fatty acid profile and in silico pharmacological study of diatom Amphora sp
Amphora sp. is a type of potential microalgae that has a considerably high content of lipid.
![Effect of Fremanezumab Monthly and Quarterly Doses on Efficacy Responses](https://www.simulations-plus.com/wp-content/themes/simulations-plus/library/dist/img/default_square-large.jpg)
Effect of Fremanezumab Monthly and Quarterly Doses on Efficacy Responses
Exposure-response (E-R) models were developed to provide a description of the time-course of treatment effect for monthly and quarterly dosing regimens of...
![How To Improve Your Compound Design & Screening Using ADMET Property Prediction and PK Simulations Day 2](https://www.simulations-plus.com/wp-content/themes/simulations-plus/library/dist/img/default_square-large.jpg)
How To Improve Your Compound Design & Screening Using ADMET Property Prediction and PK Simulations Day 2
Simulations Plus, in partnerships with pharmaceutical companies globally, has made significant investments in its ADMET Predictor® platform to implement...
![GastroPlus® Tutorial: Phase 1: Prediction of plasma concentration](https://www.simulations-plus.com/wp-content/themes/simulations-plus/library/dist/img/default_square-large.jpg)
GastroPlus® Tutorial: Phase 1: Prediction of plasma concentration
The goal is to predict the plasma concentration time following intravenous administration using a compartmental model.
![How To Improve Your Compound Design & Screening Using ADMET Property Prediction and PK Simulations Day 1](https://www.simulations-plus.com/wp-content/themes/simulations-plus/library/dist/img/default_square-large.jpg)
How To Improve Your Compound Design & Screening Using ADMET Property Prediction and PK Simulations Day 1
Simulations Plus, in partnerships with pharmaceutical companies globally, has made significant investments in its ADMET Predictor® platform to implement...
![Effect of the structural factors of organic compounds on the acute toxicity toward Daphnia magna](https://www.simulations-plus.com/wp-content/themes/simulations-plus/library/dist/img/default_square-large.jpg)
Effect of the structural factors of organic compounds on the acute toxicity toward Daphnia magna
The acute toxicity of organic compounds towards Daphina magna was subjected to QSAR analysis.