Slides from the OPCO Fireside Chat
Setting up a simulation from scratch in Simulx
No matter how you have developed your population PK/PD or QSP model, Simulx-GUI is an intuitive, flexible and powerful application to simulate new situations and answer "what if" questions.
Simulations Plus Publishes its Inaugural Environmental, Social and Governance (ESG) Report
Simulations Plus, Inc. (Nasdaq: SLP), a leading provider of modeling and simulation solutions for the pharmaceutical, biotechnology, chemicals...
Effect of QTC-4-MeOBnE Treatment on Memory, Neurodegeneration, and Neurogenesis in a Streptozotocin-Induced Mouse Model of Alzheimer’s Disease
Growing evidence suggests that drugs targeting neurogenesis and myelinization could be novel therapeutic targets against Alzheimer’s disease (AD).
Modulating target engagement of small molecules via drug delivery: approaches and applications in drug discovery and development
Drug-delivery technologies for modified drug release have been in existence for decades, but their utilization has been largely limited..
Insights of Tris(2-pyridylmethyl)amine as anti-tumor agent for osteosarcoma: experimental and in silico studies
Osteosarcoma (OS) is a malignant bone tumor and its occurrence is associated with high levels of microRNAs (miRNAs) and critical protein involved on intracellular signaling pathways.
The Intestinal Efflux Transporter Inhibition Activity of Xanthones from Mangosteen Pericarp: An In Silico, In Vitro and Ex Vivo Approach
The capacity of α-mangostin (α-MG) and β-mangostin (β-MG) from mangosteen pericarp on P-glycoprotein (Pgp) in silico, in vitro...
Proving the Mode of Action of Phytotoxic Phytochemicals
Knowledge of the mode of action of an allelochemical can be valuable for several reasons, such as proving and...
Computational evaluation of endocrine activity of biocidal active substances
Exposure to endocrine disrupting chemicals is an important public health concern although only a few endocrine disruption chemicals have been identified so far.
AAPS VCU Chapter Webinar
GastroPlus applications to various drug delivery routes of administration.
Secure your 2021 Model Informed Drug Development (MIDD), PBPK or PBBM goals – Use your 2020 year-end budget today!
In 2021, we are committed to expanding our collaborations to advance the science of drug development, reduce the time and cost of research, and improve patient wellness. With this commitment, we are extending an exclusive offer for training and regulatory advice and support at 2020 rates for use next year.
Population pharmacokinetics of MYL-1401O (a trastuzumab biosimilar) and reference trastuzumab (Herceptin®) in patients with HER2-positive metastatic breast cancer
Mylan trastuzumab (MYL-1401O) is a biosimilar to trastuzumab (Herceptin®)
A Latent Variable Approach to Account for Correlated Inputs in Global Sensitivity
In pharmaceutical research and development decision-making related to drug candidate selection, efficacy and safety...
A latent variable approach to account for correlated inputs in global sensitivity analysis with cases from pharmacological systems modelling
In pharmaceutical research and development decision-making related to drug candidate selection...
DILI-sim Initiative
Consortium distributing and developing software for predicting and preventing drug-induced liver injury
DILIsym Services Presents Important DILIsym and NAFLDsym Software Applications at the Virtual AASLD Liver Meeting
2020 Virtual Liver Meeting Posters Showcase Customer Applications
6 Things You Need to Know about Diane Longo
Find out what inspires Diane Longo in her scientific research, proudest moments, and where Alec Baldwin fits in
BCS Class IV Oral Drugs and Absorption Windows: Regional-Dependent Intestinal Permeability of Furosemide
Biopharmaceutical classification system (BCS) class IV drugs (low-solubility low-permeability) are generally poor drug candidates, yet...
GastroPlus® Tutorial: Phase 2 Video 5 Population Simulation in GastroPlus
In this video we'll be talking about population simulations.