Luann Phillips, Distinguished Scientist of Pharmacometrics, discusses the issues, repercussions, and methods in her presentation titled, "Population Pharmacokinetic Evaluation and
Missed-Dose Simulations for Eslicarbazepine Acetate Monotherapy in Patients With Partial-Onset Seizures"
In the CLARITY trial, a placebo-controlled, phase 2 trial of patients with major depressive disorder and inadequate reposnse to selective serotonin reuptake...
Evolving relationship between M&S and pharma R&D
The aim of this study was to predict the plasma concentrations of acebutolol tablets with different dissolution profiles using computer modelling and evaluating whether they are bioequivalent using simulated population studies.
Preclinical M&S Track
ADMET Predictor Overview
Bevacizumab-pemetrexed/cisplatin is a first-line therapeutic for advanced nonsquamous non-small cell lung cancer.
Application of Modeling & Simulation in Phase 1
PBPK modeling, with verification of predictive performance first performed in preclinical species, is superior to empirical methods for...
A strong, reliable tool tailored to the particular demands of the relevant endpoint that will get you...
Which dose to choose to elicit the desired effect (efficacy), without causing harm (safety)?
Dosing of 30 mg/kg Q4W could guarantee >90% inhibition of membrane-bound receptor for 9 in 10 individuals
M&S Roles in Determining Clinical Doses
Develop a simplified early PK assessment tool for non DMPK experts
Although temporarily eclipsed by the COVID-19 pandemic, tuberculosis (TB) remains the leading infectious disease-related cause of death in the world
Drug development and Phase 1 studies
Creation of a GastroPlus® project starts with structure import using ADMET Predictor Module for both substrates and perpetrators
Goal – design compounds that have high potency at the primary target...
Remdesivir, a monophosphoramidate prodrug of a nucleoside analog, has been granted Emergency Use Authorization in the U.S. for the treatment of...
Generative chemistry engine with chemically intelligent transforms
