Idiosyncratic drug-induced liver injury (iDILI) is poorlynunderstood, but there is evidence to support that some iDILI events may be immune-mediated.
Novel Synthesis and Antiviral Evaluation of New Benzothiazole-Bearing N-Sulfonamide 2-Pyridone Derivatives as USP7 Enzyme Inhibitors
In this article, a series of benzothiazole-bearing N-sulfonamide 2-pyridone derivatives were synthesized via the reaction of benzothiazole...
SAVI, in silico generation of billions of easily synthesizable compounds through expert-system type rules
We have made available a database of over 1 billion compounds predicted to be easily synthesizable, called Synthetically Accessible Virtual Inventory (SAVI).
DILIsym Plays Critical Role in Submission to State of California for Common Analgesic Carcinogenicity Risk
Comments Submitted to California’s OEHHA Featured DILIsym Simulations
Simulation of first-in-human using an allometrically scaled population mechanistic TMDD model with preclinical monkey data
First-in-human: what dose to choose to elicit the desired effect (efficacy), without causing harm (safety)?
Implementation of the C-QTc study using MonolixSuite applications
International Council for Harmonisation (ICH) E14 guidance agreed to use a model-based study of concentration-QT data as a primary analysis in...
A library of tumor growth and tumor growth inhibition models for the MonolixSuite
Modular tumor growth (TG) and tumor growth inhibition (TGI) library
Comparison of pharmacokinetics and QTc effect of Quizartinib in Japanese and non-Japanese patients with Relapsed/Refractory (R/R) FLT3-ITD positive acute myeloid leukemia (AML) using population pharmacokinetic (PopPK) analyses
The PopPK and C-QTc analyses were conducted to compare the pharmacokinetic (PK) profiles and QTc effect of quizartinib in Japanese...
November 2020 GastroPlus Newsletter
If you are like me, the static virtual meeting thing is very getting old.
Simulations Plus Sets Date for 4th Quarter and Fiscal Year 2020 Earnings Release and Conference Call
Conference Call to be on Monday, November 16, 2020, at 4:15 PM ET
Mechanisms of QT prolongation by buprenorphine cannot be explained by direct hERG channel block
Buprenorphine is a μ-opioid receptor (MOR) partial agonist used to manage pain and addiction.
Artificial intelligence and automation in computer aided synthesis planning
In this perspective we deal with questions pertaining to the development of synthesis planning technologies over the course of recent years.
Cognigen’s Global Presence
Darcy J. Hitchcock, Christian Hove (Rasmussen) Claussen, and Lindsay Lehmann introduce themselves as our global pharmacometric leaders of Cognigen.
Hepatotoxicity of Compound V Evaluated with Quantitative Systems Toxicology
Compound V is a small molecule with potential therapeutic benefits in patients with obesity.
In Vitro and In Silico ADME-Tox Profiling and Safety Significance of Multifunctional Monoamine Oxidase Inhibitors Targeting Neurodegenerative Diseases
Herein we report in vitro metabolic stability in human liver microsomes (HLMs), interactions with cytochrome P450...
Liquid Biopsy Enables Quantification of the Abundance and Interindividual Variability of Hepatic Enzymes and Transporters
Variability in individual capacity for hepatic elimination of therapeutic drugs is well recognized and is associated with variable expression and activity...
Applications of Physiologically Based Biopharmaceutics Modeling (PBBM) to Support Drug Product Quality: A Workshop Summary Report
This report summarizes the proceedings for Day 3 of the workshop titled “ Current State and Future Expectations of Translational Modeling Strategies...