The pharmacokinetics of renally eliminated antibiotics can be influenced by changes associated with renal function and development in a growing subject. Little is known about the effects of renal insufficiency on the pharmacokinetics of meropenem in pediatric subjects.
Evaluating the effectiveness of intranasal reversal agents using FDA’s translational model of opioid overdose
The number of opioid overdose deaths in the United States has continued to increase for more than two decades.
Association Between Abatacept Exposure Levels and Infection Occurrence in Patients with Rheumatoid Arthritis: Post Hoc Analysis of the AVERT-2 Study
To determine if higher serum exposure during subcutaneous (SC) abatacept treatment was associated with an increased infection risk in adult patients with early rheumatoid arthritis (RA).
Representing a Drug in a Complement QSP Model: Eculizumab as a Case Study
This blog post continues our ongoing series on leveraging quantitative systems pharmacology (QSP) to enhance drug development.
Molecular Docking, ADMET, DFT Studies, and Retrosynthesis Strategy of New Benzimidazolone Derivatives as HIV-1 Reverse Transcriptase (RT) Inhibitors
HIV-1, or Human Immunodeficiency Virus type 1, is a global pandemic that affects millions of individuals worldwide.
Simulations Plus Supported Development of Majority of FDA-Approved Drugs in 2024
SLP’s technology and expertise accelerates drug development and supports critical advancements in global healthcare
Choosing Your PK/PD Modeling Software: Key Questions About Monolix, Answered
When it comes to PK/PD modeling, many researchers stick with the tools they know, even when those tools may not be the most efficient or insightful.
Simulations Plus Reports First Quarter Fiscal 2025 Financial Results
Total revenue up 31% year-over-year primarily driven by strong software growth
Formulation Development and Evaluation, in silico PBPK Modeling and in vivo Pharmacodynamic Studies of Clozapine Matrix Type Transdermal Patches
Clozapine is a potent serotonin receptor antagonist and commonly used for the treatment of Schizophrenia.
Multi-Criteria Decision Analysis in Drug Discovery
Drug discovery is inherently a multi-criteria optimization problem.
Neuropharmacological Profile of New Thiazepinone and Thiazolidinone Compounds Designed by Virtual Screening
To evaluate the neuropharmacological profile of new spiro thiazepinone and thiazolidinone compounds in CD1 mice after a computer-aided virtual screening based on a GABA-A/BZD site.
Improving Individualized Salbutamol Treatment: A Population Pharmacokinetic Model for Oral Salbutamol in Virtual Patients
Salbutamol, a short-acting β2-agonist used in asthma treatment, is available in multiple formulations, including inhalers, nebulizers, oral tablets, and intravenous, intramuscular, and subcutaneous routes.
Characterization of Preclinical Radio ADME Properties of ARV-471 for Predicting Human PK Using PBPK Modeling
Proteolysis-targeting chimeras (PROTACs) represent a promising class of drugs that can target disease-causing proteins more effectively than traditional small molecule inhibitors can, potentially revolutionizing drug discovery and treatment strategies.
In silico Model to Predict Dermal Absorption of Chemicals in Finite Dose Conditions
The development of in silico approaches that can estimate the dermal absorption of chemicals exposed in practical conditions is highly anticipated. In the present study, an in silico model to estimate both the dermal absorption rate and dermal permeation profile was developed for the application of chemicals in finite dose conditions.
10 Most Read Journal Articles of 2024
In an industry that’s constantly evolving, staying ahead of the curve is crucial. Every breakthrough, every new piece of research can shape the future—and if you’re not in the loop, you risk falling behind.
Advancing Systemic Toxicity Risk Assessment: Evaluation of a NAM-based Toolbox Approach
For many years, a method that allowed systemic toxicity safety assessments to be conducted without generating new animal test data, seemed out of reach.
Establishment of Biopredictive Dissolution and Bioequivalence Safe Space Using the Physiologically Based Biopharmaceutics Modeling for Tacrolimus Extended-Release Capsules
A slight variation in in vivo exposure for tacrolimus extended-release (ER) capsules, which have a narrow therapeutic index (NTI), significantly affects the pharmacodynamics of the drug. Generic drug bioequivalence (BE) standards are stricter, necessitating accurate assessment of the rate and extent of drug release.
Advancements in Ocular Modelling and Simulations: Key Considerations and Case Studies
This review paper discusses the key aspects of ocular biopharmaceutics, with emphasis on the crucial role played by ocular compartmental modelling and simulation in deciphering physiological conditions related to various eye diseases.
Modeling and Simulation of AcetaminophenPharmacokinetics and Hepatic Biomarkers After Overdosesof Extended-Release and Immediate-Release Formulationsin Healthy Adults Using the Quantitative SystemsToxicology Software Platform DILIsym
Acetaminophen (APAP) has been formulated as immediate-, modified-, and extended-release tablets (APAP-IR, -MR, and -ER,respectively).