A critical review on approaches to generate and validate virtual population for physiologically based pharmacokinetic models: Methodologies, case studies and way forward

A critical review on approaches to generate and validate virtual population for physiologically based pharmacokinetic models: Methodologies, case studies and way forward

Publication: Eur J Clin Pharmacol
Software: GastroPlus®
Division: PBPK

In silico modeling and simulation techniques such as physiologically based pharmacokinetic (PBPK) and physiologically based biopharmaceutics modeling (PBBM) have demonstrated various applications in drug discovery and development.

Preparation and Evaluation of Nanolipid Carriers of Bedaquiline- In vitro Evaluation and in silico Prediction

Preparation and Evaluation of Nanolipid Carriers of Bedaquiline- In vitro Evaluation and in silico Prediction

Publication: Jordan Journal of Pharmaceutical Sciences
Software: GastroPlus®
Division: PBPK

Bedaquiline, a potent antitubercular drug used in the treatment of multidrug-resistant strains, suffers from low oral bioavailability, a slow onset of therapeutic action, and side effects.

Effect of Data Quality and Data Quantity on the Estimation of Intrinsic Solubility: Analysis Based on a Single-Source Data Set

Effect of Data Quality and Data Quantity on the Estimation of Intrinsic Solubility: Analysis Based on a Single-Source Data Set

Publication: Mol Pharm
Software: ADMET Predictor®
Division: Cheminformatics

Aqueous solubility is one of the most important physicochemical properties of drug molecules and a major driving force for oral drug absorption.

Phase I Clinical Trial of NH130 and the Prediction of its Pharmacokinetics Using Physiologically Based Pharmacokinetic Modeling

Phase I Clinical Trial of NH130 and the Prediction of its Pharmacokinetics Using Physiologically Based Pharmacokinetic Modeling

Authors: Zhang K, Zhao S, Du J, Zhang L
Publication: Front Pharmacol
Software: GastroPlus®
Division: PBPK

Parkinson’s disease psychosis (PDP) is a common and distressing complication of Parkinson’s disease (PD), characterized by hallucinations and delusions.