Predicting the Efficacy of Obeticholic Acid Treatment for Non-Alcoholic Steatohepatitis (NASH) Using NAFLDsym, a Quantitative Systems Pharmacology Model of Non-Alcoholic Fatty Liver Disease

Predicting the Efficacy of Obeticholic Acid Treatment for Non-Alcoholic Steatohepatitis (NASH) Using NAFLDsym, a Quantitative Systems Pharmacology Model of Non-Alcoholic Fatty Liver Disease

Authors: Woodhead JL, Yang K, Singh FA, Schmidt BJ, Siler SQ, Generaux GT
Conference: AAPS
Keywords: farnesoid X receptor (FXR), FGF19, NAFLDsym, NASH, Non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), obeticholic acid (OCA), PBPK modeling, quantitative systems pharmacology (QSP)
Software: NAFLDsym®
Division: Quantitative Systems Pharmacology (QSP)

Obeticholic acid (OCA), a bile acid analog and agonist of the farnesoid X receptor (FXR), is currently in clinical trials...

Deep eutectic liquid as transdermal delivery vehicle of Risperidone

Deep eutectic liquid as transdermal delivery vehicle of Risperidone

Authors: Daadoue S, Al-Remawi M, Al-Mawla L, Idkaidek N, Khalid RM, Al-Akayleh F
Publication: Journal Molecular Liquids
Keywords: dermal absorption, gastroplus, in vitro skin penetration, PBPK modeling, Skin permeation, topical administration
Software: GastroPlus®

The work outlined herein describes an evaluation of a green solvent working as a drug solubility and penetration enhancer made up of a deep eutectic system (DES) composed of menthol (MN) and capric acid (CA).