Physiologically Based Biopharmaceutics Modeling of Food Effect for Basmisanil: A Retrospective Case Study of the Utility for Formulation Bridging

Physiologically Based Biopharmaceutics Modeling of Food Effect for Basmisanil: A Retrospective Case Study of the Utility for Formulation Bridging

Authors: Belubbi T, Bassani D, Stillhart C, Parrott N
Publication: Pharmaceutics
Keywords: ACAT, bioequivalence, biopharmaceutics, fed state, gastroplus, mechanistic absorption, pbbm, PBPK modeling, physiologically based pharmacokinetics, vbe
Software: GastroPlus®

Basmisanil, is a lipophilic drug substance, exhibiting poor solubility and good permeability (BCS class 2). A validated physiologically based biopharmaceutics model (PBBM)...

Oral administration of VDAC1-derived small molecule peptides increases circulating testosterone levels in male rats

Oral administration of VDAC1-derived small molecule peptides increases circulating testosterone levels in male rats

Authors: Martinez-Arguelles DB, Nedow JW, Gukasyan HJ, Papadopoulos V
Publication: Front Endocrinol
Keywords: admet predictor, animal model, cholesterol, hormones, molecule peptides, testosterone
Software: ADMET Predictor®

Cholesterol is the precursor of all steroid hormones, and the entry of cholesterol into the mitochondria is the rate-limiting step of steroidogenesis.

Regulatory utility of physiologically based pharmacokinetic modeling for assessing food impact in bioequivalence studies: A workshop summary report

Regulatory utility of physiologically based pharmacokinetic modeling for assessing food impact in bioequivalence studies: A workshop summary report

Authors: Al Shoyaib A, Emami Riedmaier A, Kumar A, Roy P, Parrott NJ, Fang L, Tampal N, Yang Y, Jereb R, Zhao L, Wu F
Publication: CPT Pharmacometrics Syst Pharmacol
Keywords: ACAT, bioequivalence, biopharmaceutics, fed state, food effect, gastroplus, mechanistic absorption, pbbm, PBPK modeling, physiologically based pharmacokinetics, vbe
Software: GastroPlus®

This workshop report summarizes the presentations and panel discussion related to the use of physiologically based pharmacokinetic (PBPK) modeling approaches for food...

Structure-activity relationship read-across and transcriptomics for branched carboxylic acids

Structure-activity relationship read-across and transcriptomics for branched carboxylic acids

Authors: Wu S, Ellison C, Naciff J, Karb M, Obringer C, Yan G, Shan Y, Smith A, Wang X, Daston GP
Publication: Toxicol Sci
Keywords: admet predictor, chemicals, cosmetics, gastroplus, IVIVE, pbk, PBPK modeling, physiologically based pharmacokinetics, read-across, risk assessment
Software: GastroPlus®

The purpose of this study was to use chemical similarity evaluations, transcriptional profiling, in vitro toxicokinetic data, and physiologically based pharmacokinetic (PBPK)...

In-Depth Analysis of Physiologically Based Pharmacokinetic (PBPK) Modeling Utilization in Different Application Fields Using Text Mining Tools

In-Depth Analysis of Physiologically Based Pharmacokinetic (PBPK) Modeling Utilization in Different Application Fields Using Text Mining Tools

Authors: Krstevska A, Duriš J, Ibric S, Cvijić S
Publication: Pharmaceutics
Keywords: Modeling and simulations, pbbm, PBBM modeling, PBPK modeling, text mining, topic modeling

In the past decade, only a small number of papers have elaborated on the application of physiologically based pharmacokinetic (PBPK) modeling across different areas.

Pharmacokinetic Basis for Using Saliva Matrine Concentrations as a Clinical Compliance Monitoring in Antitumor B Chemoprevention Trials in Humans

Pharmacokinetic Basis for Using Saliva Matrine Concentrations as a Clinical Compliance Monitoring in Antitumor B Chemoprevention Trials in Humans

Authors: Bui D, McWilliams LA, Wu L, Zhou H, Wong SJ, You M, Chow DS, Singh R, Hu M
Publication: Cancers (Basel)
Keywords: ACAT, gastroplus, mechanistic absorption, Oncology, pbbm, PBPK modeling, physiologically based pharmacokinetics

This study reports the first clinical evidence of significantly high secretion of matrine in a multi-component botanical (Antitumor B, ATB) into human saliva from the systemic...

Prediction of Drug Synergism between Peptides and Antineoplastic Drugs Paclitaxel, 5-Fluorouracil, and Doxorubicin Using In Silico Approaches

Prediction of Drug Synergism between Peptides and Antineoplastic Drugs Paclitaxel, 5-Fluorouracil, and Doxorubicin Using In Silico Approaches

Authors: Vale N, Pereira M, Santos J, Moura C, Marques L, Duarte D
Publication: Int J Mol Sciences
Keywords: ACAT, admet predictor, dose optimization, gastroplus, mechanistic absorption, PBPK modeling, physiologically based pharmacokinetics
Software: GastroPlus®

Chemotherapy is the main treatment for most early-stage cancers; nevertheless, its efficacy is usually limited by drug resistance, toxicity, and tumor heterogeneity.