Mechanistic modeling of intramuscular administration of long-acting injectable suspensions accounting for fibrosis at the depot site

Mechanistic modeling of intramuscular administration of long-acting injectable suspensions accounting for fibrosis at the depot site

Conference: AAPS
Software: GastroPlus®
Division: PBPK

Antipsychotic drugs formulated as long-acting injectables (LAIs) significantly improve patient compliance compared to regimens that require daily oral administration.

Physiologically Based Pharmacokinetic (PBPK) Modeling of Fexofenadine and Assessment of Transporter DDIs of Fexofenadine with P-gp inducers and inhibitors

Physiologically Based Pharmacokinetic (PBPK) Modeling of Fexofenadine and Assessment of Transporter DDIs of Fexofenadine with P-gp inducers and inhibitors

Conference: AAPS
Software: GastroPlus®
Division: PBPK

Fexofenadine (FEX), a H1-receptor antagonist used in the treatment of allergic rhinitis and chronic idiopathic urticaria, undergoes minimal metabolism and transporters play a major role in its absorption and disposition.

Comprehensive Physiologically Based Pharmacokinetic Model to Assess Drug–Drug Interactions of Phenytoin

Comprehensive Physiologically Based Pharmacokinetic Model to Assess Drug–Drug Interactions of Phenytoin

Publication: Pharmaceutics
Software: GastroPlus®
Division: PBPK

Regulatory agencies worldwide expect that clinical pharmacokinetic drug–drug interactions (DDIs) between an investigational new drug...

Pharmacokinetics of the novel 5-HT4 receptor agonist, DA-6886, in dogs

Pharmacokinetics of the novel 5-HT4 receptor agonist, DA-6886, in dogs

Authors: Lee DY, Kang HE
Publication: Xenobiotica

The pharmacokinetics of a new 5-hydroxytryptamine receptor 4 agonist, DA-6886, intended for the treatment of constipation-predominant irritable bowel syndrome...

Population Pharmacokinetics of Molnupiravir in Adults With COVID-19: Lack of Clinically Important Exposure Variation Across Individuals

Population Pharmacokinetics of Molnupiravir in Adults With COVID-19: Lack of Clinically Important Exposure Variation Across Individuals

Publication: CPT Pharmacometrics Syst Pharmacol

Effective antiviral treatments for coronavirus disease 2019 (COVID-19) are needed to reduce the morbidity and mortality associated with severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) infection, particularly...

From Target Identification to Novel Lead: How Multi-omics Analysis and AI-driven Drug Design Can Accelerate Early Drug Discovery

From Target Identification to Novel Lead: How Multi-omics Analysis and AI-driven Drug Design Can Accelerate Early Drug Discovery

Software: ADMET Predictor®
Division: PBPK

One of the key areas for optimization in the drug development process is the discovery stage. Traditional methods are time-consuming and often produce leads that ultimately fail.

Virtual Docking, design and in silico ADMET profiling of novel Rho-associated protein kinases-1 (ROCK1) inhibitors

Virtual Docking, design and in silico ADMET profiling of novel Rho-associated protein kinases-1 (ROCK1) inhibitors

Publication: 2nd International Conference on Chemo and BioInformatics, Kragujevac, September 28-29, 2023, Serbia
Software: ADMET Predictor®

Overexpression of Rho-associated protein kinases has been associated with various diseases, including tumors.

Application of PBBM and virtual bioequivalence to support formulation development and define dissolution specification, two case studies

Application of PBBM and virtual bioequivalence to support formulation development and define dissolution specification, two case studies

Authors: Nabais E, Martins F
Software: GastroPlus®
Division: PBPK

During this webinar, we will shed light on the key benefits and practical implications of utilizing in-silico modeling for formulation development, biopharmaceutical predictions, and bioequivalence studies.