Safety of a higher loading dose of phenobarbital in the term newborn

Safety of a higher loading dose of phenobarbital in the term newborn

Authors: Donn SM, Grasela TH, Goldstein GW
Publication: Pediatrics
Keywords: adverse effects, Asphyxia Neonatorum, blood, drug therapy, half-life, humans, infant, newborn, pediatrics, phenobarbital, seizures, standards, therapeutic use
Division: Clinical Pharmacology and Pharmacometrics (CPP)

The conventional loading dose of phenobarbital for newborn infants with hypoxic-ischemic seizures, 20 mg/kg, often fails to control convulsive activity.

Neonatal Population Pharmacokinetics of Phenobarbital Derived from Routine Clinical Data

Neonatal Population Pharmacokinetics of Phenobarbital Derived from Routine Clinical Data

Authors: Grasela TH, Donn SM
Publication: Dev Pharmacol Ther
Keywords: AED, analysis, biological, birth weight, central nervous system agents, gestational age, half-life, humans, infant, kinetics, metabolism, models, neurology, newborn, P.H.S., pediatrics, pharmacokinetics, phenobarbital, population, premature, research support, therapy, U.S. Government
Division: Clinical Pharmacology and Pharmacometrics (CPP)

Routine clinical pharmacokinetic (PK) data collected from 59 preterm infants who received phenobarbital were analyzed to estimate population PK parameters. Birth weights ranged from 600 to 3,620 g...

A calculator program for clinical application of the Bayesian method of predicting plasma drug levels

A calculator program for clinical application of the Bayesian method of predicting plasma drug levels

Authors: Ruffo S, Messori A, Grasela TH, Longo G, Donati-Cori G, Matucci M, Morfini M, Tendi E
Publication: Comput Programs Biomed
Keywords: administration & dosage, biological, blood, computers, drug therapy, Factor Viii, Hemophilia A, humans, kinetics, metabolism, Microcomputers, models, pharmaceutical preparations, plasma, population, Software
Division: Clinical Pharmacology and Pharmacometrics (CPP)

A pharmacokinetic program that allows individualization of drug dosage regimens through the Bayesian method is described.

Population Pharmacokinetics of Procainamide from Routine Clinical Data

Population Pharmacokinetics of Procainamide from Routine Clinical Data

Authors: Grasela TH, Sheiner LB
Publication: Clin Pharmacokinet
Keywords: analysis, arrhythmia, biological, cardiology, cardiovascular agents, congestive, drug therapy, female, heart, heart failure, humans, kinetics, male, metabolism, middle-aged, models, P.H.S., pharmacokinetics, plasma, population, procainamide, research support, therapeutic use, U.S. Government
Division: Clinical Pharmacology and Pharmacometrics (CPP)

Routine clinical pharmacokinetic data collected from patients receiving procainamide were analysed to estimate population pharmacokinetic parameters. 116 plasma concentration determinations for procainamide...

Experience with NONMEM: Analysis of Routine Phenytoin Clinical Pharmacokinetic Data

Experience with NONMEM: Analysis of Routine Phenytoin Clinical Pharmacokinetic Data

Authors: Sheiner LB, Grasela TH
Publication: Drug Metab Rev
Keywords: AED, analysis, biological, central nervous system agents, computers, humans, kinetics, metabolism, methods, models, neurology, NONMEM, P.H.S., phenytoin, PKPD methodology, population, research support, U.S. Government
Division: Clinical Pharmacology and Pharmacometrics (CPP)

NONMEM, a program package the produces the extended least squares estimates of population parameters for a nonlinear mixed-effect model, has been applied to two data sets from patients routinely...

Steady-State Pharmacokinetics of Phenytoin from Routinely Collected Patient Data

Steady-State Pharmacokinetics of Phenytoin from Routinely Collected Patient Data

Authors: Grasela TH, Sheiner LB, Rambeck B, Boenigk HE, Dunlop A, Mullen PW, Wadsworth J, Richens A, Ishizaki T, Chiba K, Miura H, Minagawa K, Blain PG, Mucklow JC, Bacon CT, Rawlins M
Publication: Clin Pharmacokinet
Keywords: adolescent, adult, AED, analysis, biological, central nervous system agents, female, humans, kinetics, male, metabolism, models, NONMEM, pharmacokinetics, phenytoin, population, research support, U.S. Government
Division: Clinical Pharmacology and Pharmacometrics (CPP)

Previously reported routine Phenytoin clinical pharmacokinetic data from Japan, England, and Germany were analysed to estimate population pharmacokinetic parameters. There were 780 steady-state…