An Evaluation of Point and Interval Estimates in Population Pharmacokinetics Using NONMEM Analysis

An Evaluation of Point and Interval Estimates in Population Pharmacokinetics Using NONMEM Analysis

Publication: J Pharmacokinet Biopharm

In a simulation study of the estimation of population pharmacokinetic parameters, including fixed and random effects, the estimates and confidence intervals produced by NONMEM were evaluated.

Prospective Surveillance of Intravenous Amphotericin B Use Patterns

Prospective Surveillance of Intravenous Amphotericin B Use Patterns

Publication: Pharmacotherapy

Information on amphotericin B use patterns and infusion-related adverse events were prospectively collected from 397 hospitalized adults. The methods of initiating amphotericin B varied greatly, with the…

A Nationwide Survey of Prescribing Patterns for Thrombolytic Drugs in Acute Myocardial Infarction

A Nationwide Survey of Prescribing Patterns for Thrombolytic Drugs in Acute Myocardial Infarction

Authors: Grasela TH, Green JA
Publication: Pharmacotherapy

In November 1988, 164 hospitals enrolled in the Drug Surveillance Network participated in a nationwide survey of prescribing patterns for thrombolytic drugs for patients with an acute myocardial infarction.

The Influence of Intravenous Cimetidine Dosage Regimens on the Disposition of Theophylline

The Influence of Intravenous Cimetidine Dosage Regimens on the Disposition of Theophylline

Publication: J Clin Pharmacol

The influence of the method of cimetidine administration on theophylline disposition was studied in nine healthy, cigarette smoking male volunteers. The treatment phases consisted of: A) theophylline...

Prospective Surveillance of Antibiotic-Associated Coagulopathy in 970 Patients

Prospective Surveillance of Antibiotic-Associated Coagulopathy in 970 Patients

Publication: Pharmacotherapy

N-methyl-thio-tetrazole (NMTT) has been proposed as a causative factor in antibiotic-associated coagulopathy. To evaluate this hypothesis, a nationwide surveillance program was initiated to determine...

The Population Pharmacokinetics of Theophylline in Neonates and Young Infants

The Population Pharmacokinetics of Theophylline in Neonates and Young Infants

Publication: J Pharmacokinet Biopharm

The population pharmacokinetics of theophylline were evaluated using 391 theophylline serum concentration measurements from 108 neonates and young infants (postnatal age 0-26 weeks), who received...

A Clinical Pharmacy-Oriented Drug Surveillance Network: II. Results of a Pilot Project

A Clinical Pharmacy-Oriented Drug Surveillance Network: II. Results of a Pilot Project

Publication: Drug Intell Clin Pharm

A nationwide network of clinical pharmacists has been organized for the purpose of collecting drug experience data generated during the routine clinical care of patients. In order to assess the utility...

A Clinical Pharmacy-Oriented Drug Surveillance Network: I. Program Description

A Clinical Pharmacy-Oriented Drug Surveillance Network: I. Program Description

Publication: Drug Intell Clin Pharm

The limitations of the new drug development process, particularly in regard to the evaluation of drug safety, have resulted in a need for monitoring drug experience in the postmarketing period. Although a...

Determinants of antibiotic-associated hypoprothrombinemia

Determinants of antibiotic-associated hypoprothrombinemia

Publication: Pharmacotherapy

Hypoprothrombinemia is a relatively uncommon event in the hospitalized patient. When it does occur, it often is associated with surgery, dietary vitamin K deficiency, renal dysfunction, malignancy, and broad-spectrum antibiotic therapy...

Inhibition of Theophylline Clearance by Coadministered Ofloxacin Without Alteration of Theophylline Effects

Inhibition of Theophylline Clearance by Coadministered Ofloxacin Without Alteration of Theophylline Effects

Publication: Antimicrob Agents Chemother

The influence of multiple doses of ofloxacin (ORF 18489) on the disposition of theophylline was studied in 15 male volunteers. Subjects were confined in the Clinical Research Unit for 13 days and given a...

An Evaluation of Population Pharmacokinetics in Therapeutic Trials. Part I. Comparison of Methodologies

An Evaluation of Population Pharmacokinetics in Therapeutic Trials. Part I. Comparison of Methodologies

Publication: Clin Pharmacol Ther

NONMEM, a computer program that uses the method of extended least-squares analysis, has been advocated as a means of obtaining estimates of population pharmacokinetic parameters when only fragmentary...