Experience with NONMEM: Analysis of Routine Phenytoin Clinical Pharmacokinetic Data

Experience with NONMEM: Analysis of Routine Phenytoin Clinical Pharmacokinetic Data

Authors: Sheiner LB, Grasela TH
Publication: Drug Metab Rev
Keywords: AED, analysis, biological, central nervous system agents, computers, humans, kinetics, metabolism, methods, models, neurology, NONMEM, P.H.S., phenytoin, PKPD methodology, population, research support, U.S. Government
Division: Clinical Pharmacology and Pharmacometrics (CPP)

NONMEM, a program package the produces the extended least squares estimates of population parameters for a nonlinear mixed-effect model, has been applied to two data sets from patients routinely...

Steady-State Pharmacokinetics of Phenytoin from Routinely Collected Patient Data

Steady-State Pharmacokinetics of Phenytoin from Routinely Collected Patient Data

Authors: Grasela TH, Sheiner LB, Rambeck B, Boenigk HE, Dunlop A, Mullen PW, Wadsworth J, Richens A, Ishizaki T, Chiba K, Miura H, Minagawa K, Blain PG, Mucklow JC, Bacon CT, Rawlins M
Publication: Clin Pharmacokinet
Keywords: adolescent, adult, AED, analysis, biological, central nervous system agents, female, humans, kinetics, male, metabolism, models, NONMEM, pharmacokinetics, phenytoin, population, research support, U.S. Government
Division: Clinical Pharmacology and Pharmacometrics (CPP)

Previously reported routine Phenytoin clinical pharmacokinetic data from Japan, England, and Germany were analysed to estimate population pharmacokinetic parameters. There were 780 steady-state…