Call To Be Held On Tuesday, December 13, at 4:30 PM EST
Simulations Plus Releases GastroPlus TM Version 5.0
Completion of Two-Year Development Program Adds Major New Functionalities
Simulations Plus Requests Extension for 10K-SB Filing
Company Plans Conference Call Shortly After Release
Simulations Plus Announces Change in Investor Relations
Function to be Moved In-House for Greater Operating Efficiency
Adult and Pediatric GastroPlus-PBPK Simulations of Gabapentin using in silico Population Estimates for Age-Related (PEAR) Physiology
To evaluate the accuracy of prediction of Midazolam absorption and bioavailability in a pediatric population from in silico, in vitro and adult in vivo data. The significance of scaling of the clearance and…
Population Pharmacokinetics of Tigecycline in Patients with Complicated Intra-abdominal or Skin and Skin-Structure Infections
Tigecycline is a novel glycylcycline antibiotic demonstrating broad-spectrum in vitro activity. A previously developed population pharmacokinetic (PK) model was utilized to generate individual predicted…
Population Pharmacokinetics of Modafinil Film-Coated Tablets in Children and Adolescents With Attention-Deficit/Hyperactivity Disorder
Modafinil is currently being evaluated for the treatment of attention-deficit/hyperactivity disorder (ADHD) in children and adolescents. A population pharmacokinetic model was developed…
Simulations Plus Announces Release of New Toxicity Prediction for ADMET Predictor™
hERG Potassium Channel Blocking Affinity Models Important Cardiac Toxicity
Pharmacokinetic/Pharmacodynamic Model for the Safety of Tigecycline in Patients with Complicated Skin and Skin-Structure Infections
Tigecycline is a first-in-class glycylcycline for the treatment of serious bacterial infections. Reported adverse events from clinical trials include nausea and vomiting. Exposure-response relationships and…
Challenges in the transition to model-based development
Practitioners of the art and science of pharmacometrics are well aware of the considerable effort required to successfully complete modeling and simulation activities...
An evaluation of the utility of physiologically based models of pharmacokinetics in early drug discovery
Generic physiologically-based models of pharmacokinetics were evaluated for early drug discovery.
Simulations Plus Expands Field Sales Force
Product Manager to Become Full-time Field Representative
Use of pharmacokinetic-pharmacodynamic target attainment analyses to support phase 2 and 3 dosing strategies for doripenem
A doripenem population pharmacokinetic model and Monte Carlo simulations were utilized for dose regimen decision support for future clinical development.
Simulations Plus Acquires Assets of Sage Informatics LLC
New Product Line and Key Employee Expand Software Offerings and Science Staff
Viral and cellular gene transcription in fibroblasts infected with small plaque mutants of varicella-zoster virus
Varicella-zoster virus (VZV) is an alphaherpesvirus that causes varicella and herpes zoster. In these experiments, cDNA corresponding to 69 VZV open reading frames was...
Antimicrobial safety: focus on fluoroquinolones
Infrequent toxicities associated with certain drugs and drug classes have recently gained much attention from different health-care perspectives.