Our objective was to compare the economic benefits of cefepime plus metronidazole with those of imipenem/cilastatin in the treatment of complicated intra-abdominal infections.
Pharmacokinetics, safety, and tolerability of ascending single intravenous doses of oritavancin administered to healthy human subjects
tavancin (LY333328 diphosphate) is a novel glycopeptide antimicrobial agent with potent microbiological activity in vitro against Gram-positive bacteria.
Postoperative Infection Rate Following Cardiac Surgery With Allogeneic vs Other Blood Management Techniques
Infection rates associated with allogeneic blood transfusion versus other blood management techniques were prospectively compared in elective cardiac surgery patients (anticipated blood loss > 1000 mL).
Blood Management and Infections in Cardiovascular and Orthopedic Surgery
Numerous risks are associated with allogeneic blood transfusions. Various blood management techniques have evolved which minimize or eliminate the use of allogeneic blood. This study compared infection rates…
Regional Intestinal Absorption and Biliary Excretion of Fluvastatin in the Rat: Possible Involvement of mrp2
The first purpose of this study was to investigate the in vivo absorption, biliary secretion, and first-pass effect of fluvastatin following regional intestinal dosing in the rat.
Use of pharmacodynamic end points in the evaluation of gatifloxacin for the treatment of acute maxillary sinusitis
The relationship between drug exposure and the time course of antimicrobial effect at the primary infection site for acute maxillary sinusitis has not previously been explored.
Development of clinical dosage forms for a poorly water soluble drug I: Application of polyethylene glycol–polysorbate 80 solid dispersion carrier system
Different formulation approaches were evaluated to ensure that the formulation of a poorly water soluble compound chosen during early development achieves optimum bioavailability.
Use of an in vitro Pharmacodynamic Model & Monte Carlo Simulation to Characterize the Pharmacokinetics and Pharmacodynamics of Gatifloxacin vs Salmonella Typhi
Salmonella enterica serotype Typhi and non-typohoidal Salmonella remain major causes of morbidity and mortality worldwide. Ampicillin, trimethoprim-sulfamethoxazole, and chloramphenicol no longer…
Pharmacokinetics (PK) of Tigecycline (TG) in Healthy Adult Volunteers and in Subjects with Renal Impairment
TG is a novel glycylcycline antibiotic with an expanded spectrum of activity, which includes gram-positive, gram-negative, atypical, and anaerobic pathogens. TG has also shown activity against pathogens…
The Impact of Mivacurium and Rocuronium on Recovery Times in Ambulatory Anesthesia Procedures
This study w as designed to evaluate the recovery times of patients undergoing ambulatory surgery w ith the short-acting, fastemergence anesthetic muscle relaxants, mivacurium, and rocuronium.
A Novel Pharmacodynamic Model for Gatifloxacin vs. Salmonella typhi in Timed Kill Curves
Quinolones are the mainstay of treatment for Salmonella typhi (S. typhi) infections but there is growing concern about resistance to older quinolones & poor understanding of quinolone /S. typhi…
Effect of drug solubility and different excipients on floating behaviour and release from glyceryl monooleate matrices
Glycerol monooleate (GMO) matrix was found to be a gastro-retentive carrier system suitable for both polar and as well as non-polar drugs.
Formulation and Evaluation of Mucoadhesive Tablets Containing Eugenol for the Treatment of Periodontal Diseases
Eugenol is the principle chemical constituent of clove oil and has been used to cure dental problems for ages.
Predicting drug absorption by computational methods
Simulation Studies Relevant to Oral Absorption
Simulations Plus Reports Results for First Fiscal Quarter of Fiscal Year 2004
Record 1st Quarter Revenues and 8th Consecutive Profitable Quarter
A comparative study of marketed herbal liquid oral antacid formulations: In – vitro antacid activity, antiulcer activity and microbial standardization
Number of herbal formulations are available which are claimed to have antacid and anti-ulcer activities.
Solubility Prediction by Recursive Partitioning
To build and test a computational model for predicting small molecule solubility, to improve the cost-effectiveness of the selection of vendor compounds suitable for nuclear magnetic resonance (NMR) screening.
Pharmacokinetic Analysis of Gatifloxacin in Plasma and Sinus Aspirate During Treatment of Acute Maxillary Sinusitis
A novel approach to collect sinus exudate was utilized and the time course of gatifloxacin (GAT) in the blood and at the primary infection site were assessed during treatment for acute maxillary sinusitis (AMS).
Comparison of Parametric (NONMEM®) and Non-Parametric (NPEM®) Methods for Population Pharmcokinetic Modeling of Bi-Model Populations
Debate exists whether the most appropriate population analysis method is parametric (NONMEM®) or non-parametric (NPEM®), especially for data from a bi-modal population (i.e., poor/extensive metabolizers...