Population Pharmacokinetics of Nebulized Arformoterol in Subjects with COPD

Population Pharmacokinetics of Nebulized Arformoterol in Subjects with COPD

Authors: Maier G, Kharidia J, Hanrahan JP, Hsu R, Jaworowicz DJ, Cirincione B, Owen JS, Grasela TH
Conference: ERSC
Keywords: bronchodilator, chronic obstructive pulmonary disease, FEV, forced expiratory volume, formoterol, inhaled, NONMEM, PE%, PK, pulmonology, respiratory, respiratory agents, weight
Division: Clinical Pharmacology and Pharmacometrics (CPP)

(R,R)-Formoterol (ARF) is a highly selective, potent and long-acting β2-adrenoceptor agonist currently under development in the US for the longterm maintenance treatment of bronchoconstriction associated…

Exposure-Response Relationship for Nebulized Arformoterol in Subjects with COPD

Exposure-Response Relationship for Nebulized Arformoterol in Subjects with COPD

Authors: Maier G, Kharidia J, Hanrahan JP, Hsu R, Jaworowicz DJ, Cirincione B, Owen JS, Grasela TH
Conference: ERSC
Keywords: biophase, bronchodilator, chronic obstructive pulmonary disease, Emax, FEV, forced expiratory volume, formoterol, hypothetical compartment, hysteresis, inhaled, link model, NONMEM, PK/PD, pulmonology, respiratory agents, SAS, steady state, time lag
Division: Clinical Pharmacology and Pharmacometrics (CPP)

Arformoterol (ARF) is a highly selective, potent, long-acting β2-adrenoceptor agonist under development in the US for the maintenance treatment of bronchoconstriction associated with COPD. An initial…

Biorelevant dissolution media as a predictive tool for glyburide a class II drug

Biorelevant dissolution media as a predictive tool for glyburide a class II drug

Authors: Wei H, Loebenberg R
Publication: Eur J Pharm Sci
Keywords: biorelevant dissolution media (BDM), computer simulation, dynamic dissolution, in silico, in vitro, in vitro dissolution, in vitro-in vivo correlation (IVIVC), oral drug absorption, permeability, solubility
Software: GastroPlus®

The purpose of this study was to predict the oral absorption of glyburide. Biorelevant dissolution methods, combined with permeability measurements and computational simulations, were used...

In Silico Modeling of Non-Linear Drug Absorption for the P-gp Substrate Talinolol and of Consequences for the Resulting Pharmacodynamic Effect

In Silico Modeling of Non-Linear Drug Absorption for the P-gp Substrate Talinolol and of Consequences for the Resulting Pharmacodynamic Effect

Authors: Tubic-Grozdanis M, Wagner D, Spahn-Langguth H, Bolger MB, Langguth P
Publication: AAPS J
Keywords: absorption, intestinal efflux, P-glycoprotein, pharmacokinetics, simulation, talinolol
Software: GastroPlus®
Division: PBPK

The aim of the present work was to demonstrate P-glycoprotein's involvement in the non-linear talinolol pharmacokinetics using an advanced compartment and transit model (ACAT) and to compare...

Inhibition of the NF-kappaB pathway by varicella-zoster virus in vitro and in human epidermal cells in vivo

Inhibition of the NF-kappaB pathway by varicella-zoster virus in vitro and in human epidermal cells in vivo

Authors: Jones JO, Arvin AM
Publication: J Virol
Keywords: cellular antiviral response, kappa B (NF-kappaB)-responsive genes, varicella-zoster virus (VZV)
Division: PBPK

Varicella-zoster virus (VZV) is an alphaherpesvirus that causes varicella and herpes zoster. Using human cellular DNA microarrays, we found that many nuclear factor kappa B...

Pharmacokinetic/Pharmacodynamic (PK/PD) Model for the Safety of Tigecycline (T) in Patients with Complicated Intra-Abdominal Infections (cIAI)

Pharmacokinetic/Pharmacodynamic (PK/PD) Model for the Safety of Tigecycline (T) in Patients with Complicated Intra-Abdominal Infections (cIAI)

Authors: Meagher AK, Liolios K, Passarell JA, Cirincione B, Van Wart S, Fiedler-Kelly J, Babinchak T, Ellis-Grosse EJ
Conference: ECCMID
Keywords: anti-infectives, antibiotic, antiemetic, cIAI, cSSSI, female, hosmer-lemeshow, infectious disease, Kaplan-Meier, logistic regression, nausea, region, ROC, SAS, vomiting, weight
Division: Clinical Pharmacology and Pharmacometrics (CPP)

Nausea (N) and vomiting (V) have been reported with tigecycline, a new glycylcycline with expanded broad spectrum activity. 140 exposure-response relationships and patient covariates predictive of the first N…

NIPALSTREE:  A New Hierarchical Clustering Approach for Large Compound Libraries and Its Application to Virtual Screening

NIPALSTREE:  A New Hierarchical Clustering Approach for Large Compound Libraries and Its Application to Virtual Screening

Authors: Böcker A, Schneider G, Teckentrup A
Publication: J Chem Inf Model
Keywords: angiotensin converting enzyme (ACE) inhibitors, chemotypes, hierarchical clustering algorithm, MDL Drug Data Report (MDDR)
Software: MedChem Studio™

A hierarchical clustering algorithm NIPALSTREE was developed that is able to analyze large data sets in high-dimensional space. The result can be displayed as a dendrogram.