Serial sinus aspirate samples during high-dose, short-course levofloxacin treatment of acute maxillary sinusitis

Serial sinus aspirate samples during high-dose, short-course levofloxacin treatment of acute maxillary sinusitis

Authors: Anon JB, Paglia M, Xiang J, Ambrose PG, Jones RN, Kahn JB
Publication: Diagn Microbiol Infect Dis
Keywords: Acute Disease, administration & dosage, adult, adverse effects, anti-bacterial agents, Catheters, Dose-Response Relationship, drug, drug administration schedule, drug effects, drug therapy, female, Haemophilus Infections, Haemophilus influenzae, Indwelling
Division: Clinical Pharmacology and Pharmacometrics (CPP)

This study assessed daily aspirate samples from an indwelling sinus catheter during high-dose, short-course levofloxacin (750 mg daily x 5 days) treatment...

Pharmacodynamics of cefprozil against Haemophilus influenzae in an in vitro pharmacodynamic model

Pharmacodynamics of cefprozil against Haemophilus influenzae in an in vitro pharmacodynamic model

Authors: Smith PF, Tsuji B, Booker BM, Forrest A, Bajic S, Kelchlin P, Bhavnani SM, Jones RN, Ambrose PG
Publication: Diagn Microbiol Infect Dis
Keywords: anti-bacterial agents, cephalosporins, Dose-Response Relationship, drug, drug effects, drug therapy, growth & development, Haemophilus Infections, Haemophilus influenzae, humans, in vitro, methods, Microbial Sensitivity Tests, microbiology, otitis media
Division: Clinical Pharmacology and Pharmacometrics (CPP)

An in vitro pharmacodynamic model was used to determine the pharmacokinetic-pharmacodynamic (PK-PD) measure and magnitude most strongly related...

Population pharmacokinetics of risperidone and 9-hydroxyrisperidone in patients with acute episodes associated with bipolar I disorder

Population pharmacokinetics of risperidone and 9-hydroxyrisperidone in patients with acute episodes associated with bipolar I disorder

Authors: Vermeulen A, Piotrovsky V, Ludwig EA
Publication: J Pharmacokinet Pharmacodyn
Keywords: Acute Disease, administration, administration & dosage, adult, aged, antipsychotic agents, Bipolar Disorder, blood, body mass index, body weight, Carbamazepine, computer simulation, Creatinine, Cytochrome P-450 CYP2D6, Databases as Topic, Drug Admini, oral
Division: Clinical Pharmacology and Pharmacometrics (CPP)

A population model was developed with the aim to simultaneously describe risperidone and 9-hydroxyrisperidone pharmacokinetics; to obtain estimates for pharmacokinetic parameters and associated...

Selective activation of estrogen receptor-beta transcriptional pathways by an herbal extract

Selective activation of estrogen receptor-beta transcriptional pathways by an herbal extract

Authors: Cvoro A, Paruthiyil S, Jones JO, Tzagarakis-Foster C, Clegg NJ, Tatomer D, Medina RT, Tagliaferri M, Schaufele F, Scanlan TS, Diamond MI, Cohen I, Leitman DC
Publication: Endocrinology
Keywords: ERbeta-selective ligands, menopausal symptoms, Novel estrogenic therapies
Division: PBPK

Novel estrogenic therapies are needed that ameliorate menopausal symptoms and have the bone-sparing effects of endogenous estrogens but do not promote breast or...

In Silico Prediction of Ionization

In Silico Prediction of Ionization

Authors: Fraczkiewicz R
Publication: Comprehensive Medicinal Chemistry II, Vol. 5
Keywords: acid–base equilibrium, acidity, aqueous ionization, basicity, in silico prediction, ionization prediction, linear free energy relationships (LEFR), pKa, pKa prediction, quantitative structure–activity relationship (QSAR)
Software: ADMET Predictor®
Division: PBPK

The focus of this chapter is computational methods for the prediction of aqueous ionization of organic molecules.

Population pharmacokinetics of tigecycline in patients with complicated intra-abdominal or skin and skin structure infections

Population pharmacokinetics of tigecycline in patients with complicated intra-abdominal or skin and skin structure infections

Authors: Van Wart S, Owen JS, Ludwig EA, Meagher AK, Korth-Bradley JM, Cirincione BB
Publication: Antimicrob Agents Chemother
Keywords: 80 and over, abdomen, adolescent, adult, aged, analogs & derivatives, anti-bacterial agents, area under curve, bacterial infections, blood, clinical trials, Creatinine, female, humans, infection, male, metabolism, middle-aged, Minocycline, models, Tigecycline
Division: Clinical Pharmacology and Pharmacometrics (CPP)

Tigecycline, a first-in-class expanded glycylcycline antimicrobial agent, has demonstrated efficacy in the treatment of complicated skin and skin structure infections...

Population Pharmacokinetics of (R)-Albuterol Following Inhaled Levalbuterol or Racemic Albuterol via a Hydrofluoroalkane Metered Dose Inhaler in Pediatric and Adult Asthma Patients

Population Pharmacokinetics of (R)-Albuterol Following Inhaled Levalbuterol or Racemic Albuterol via a Hydrofluoroalkane Metered Dose Inhaler in Pediatric and Adult Asthma Patients

Authors: Jaworowicz DJ, Maier G, Baumgartner RA, Hsu R, Grasela TH
Conference: AAPS
Keywords: bronchodilator, enantiomer, inhaled, NONMEM, PE%, pediatrics, PK, pulmonology, respiratory agents, weight
Division: Clinical Pharmacology and Pharmacometrics (CPP)

Levalbuterol (LEV), the (R)-enantiomer of racemic albuterol (RA), is approved for the treatment or prevention of bronchospasm in patients ≥4 years of age via metered dose inhaler (MDI). A population…