Influence Of Estimation Of Inter-Occasion Variability On Detection Of Time-Varying Covariates

Influence Of Estimation Of Inter-Occasion Variability On Detection Of Time-Varying Covariates

Authors: Wu H, Hirankarn S, Fiedler-Kelly J
Conference: AAPS
Keywords: auto induction, covariates, inter occasion, IOV, methods, NONMEM, PE%, pharmacokinetic, PK, PKPD methodology, simulated data, simulation, stochastic, time varying, time-dependent
Division: Clinical Pharmacology and Pharmacometrics (CPP)

To explore the influence of the estimation of inter-occasion variability (IOV) on the ability to detect time-varying covariates influencing PK parameters from a population PK (PPK) analysis using NONMEM.

Plasma Pharmacokinetic (PK) Profile of Two Consecutive Doses of Ferumoxytol in Healthy Subjects

Plasma Pharmacokinetic (PK) Profile of Two Consecutive Doses of Ferumoxytol in Healthy Subjects

Authors: Pai A, Owen JS, Clarkin M, Nielsen J, Clark T, Lawler D, Kausz A
Conference: American Society of Nephrology (ASN)
Keywords: capacity-limited elimination, chronic kidney disease, hematology, iron, iron deficiency anemia, miscellaneous agents, nephrology, open model, two compartment, two-compartment model
Division: Clinical Pharmacology and Pharmacometrics (CPP)

Ferumoxytol is a carbohydrate-coated superparamagnetic iron oxide nanoparticle being evaluated for safety and efficacy in two distinct areas of medical need.

Prediction of Human Pharmacokinetics Using Physiologically Based Modeling: A Retrospective Analysis of 26 Clinically Tested Drugs

Prediction of Human Pharmacokinetics Using Physiologically Based Modeling: A Retrospective Analysis of 26 Clinically Tested Drugs

Authors: De Buck SS, Sinha VK, Fenu LA, Nijsen MJ, Mackie CE, Gilissen RA
Publication: Drug Metab Dispos
Keywords: body clearance, oral absorption, pharmacokinetics, Physiologically based pharmacokinetic (PBPK) modeling
Software: GastroPlus®

The aim of this study was to evaluate different physiologically based modeling strategies for the prediction of human pharmacokinetics.

Population pharmacokinetic meta-analysis of trabectedin (ET-743, Yondelis) in cancer patients

Population pharmacokinetic meta-analysis of trabectedin (ET-743, Yondelis) in cancer patients

Authors: Perez Ruixo JJ, Zannikos P, Hirankarn S, Stuyckens K, Ludwig EA, Soto-Matos A, Lopez-Lazaro L, Owen JS
Publication: Clin Pharmacokinet
Keywords: 80 and over, administration & dosage, adult, aged, analysis, antineoplastic agents, area under curve, bilirubin, Creatinine, Dioxoles, drug therapy, female, half-life, humans, infusions, intravenous, male, metabolism, methods, middle-aged, models
Division: Clinical Pharmacology and Pharmacometrics (CPP)

To characterise the population pharmacokinetics of trabectedin (ET-743, Yondelis(R)) in cancer patients.

Population pharmacokinetics of (R)-albuterol and (S)-albuterol in pediatric patients aged 4-11 years with asthma

Population pharmacokinetics of (R)-albuterol and (S)-albuterol in pediatric patients aged 4-11 years with asthma

Authors: Maier G, Rubino C, Hsu R, Grasela TH, Baumgartner RA
Publication: Pulm Pharmacol Ther
Keywords: aged, analysis, Asthma, blood, metabolism, methods, pediatrics, pharmacokinetics, pharmacology, population
Division: Clinical Pharmacology and Pharmacometrics (CPP)

To characterize the population pharmacokinetics (PK) of (R)- and (S)-albuterol in pediatric asthmatics using a model that supports a sparse blood sampling strategy.

Targeting Plague Virulence Factors: A Combined Machine Learning Method and Multiple Conformational Virtual Screening for the Discovery of Yersinia Protein Kinase A Inhibitors

Targeting Plague Virulence Factors: A Combined Machine Learning Method and Multiple Conformational Virtual Screening for the Discovery of Yersinia Protein Kinase A Inhibitors

Authors: Hu X, Prehna G, Stebbins CE
Publication: J Med Chem
Keywords: anti-plague drugs, high-throughput docking, machine learning method, Yersinia protein kinase A (YpkA)
Software: ADMET Predictor®

Yersinia spp. is currently an antibiotic resistance concern and a re-emerging disease.

Pharmacometrics and the transition to model-based development

Pharmacometrics and the transition to model-based development

Keywords: analysis, animals, clinical, computer simulation, data_assembly_and_programming, Drug Approval, drug design, Drug Information Services, humans, methods, models, New York, pharmacology, statistics & numerical data, Theoretical
Division: Clinical Pharmacology and Pharmacometrics (CPP)

As the transition to model-based drug development continues, pharmacometric analysis will have an increasingly important role across the entire life cycle of drug discovery...