Population Pharmacokinetics of Paliperidone ER in Healthy Subjects and Patients With Schizophrenia

Population Pharmacokinetics of Paliperidone ER in Healthy Subjects and Patients With Schizophrenia

Authors: Cirincione B, Redman M, Fiedler-Kelly J, Ludwig E, Vermeulen A
Conference: ASCPT
Keywords: antipsychotic, CrCL, creatinine clearance, extended release, intravenous, IV, lag time, LBM, lean body mass, NONMEM, oral, OROS, phenotype, PK, psychiatry, psychotherapeutic agents
Division: Clinical Pharmacology and Pharmacometrics (CPP)

To develop a population pharmacokinetic (PPK) model for paliperidone extended-release (ER) and to evaluate the influence of selected covariates.

Informatics: the fuel for pharmacometric analysis

Informatics: the fuel for pharmacometric analysis

Authors: Grasela TH, Fiedler-Kelly J, Cirincione B, Hitchcock D, Reitz K, Sardella S, Smith B
Publication: AAPS J
Keywords: analysis, data assembly, data_assembly_and_programming, decision-making, forensic pharmacometrics, informatics, methods, models, pharmaceutical, pharmacokinetics, Technology, Theoretical
Division: Clinical Pharmacology and Pharmacometrics (CPP)

The current informal practice of pharmacometrics as a combination art and science makes it hard to appreciate the role that informatics can and should...

Serial sinus aspirate samples during high-dose, short-course levofloxacin treatment of acute maxillary sinusitis

Serial sinus aspirate samples during high-dose, short-course levofloxacin treatment of acute maxillary sinusitis

Authors: Anon JB, Paglia M, Xiang J, Ambrose PG, Jones RN, Kahn JB
Publication: Diagn Microbiol Infect Dis
Keywords: Acute Disease, administration & dosage, adult, adverse effects, anti-bacterial agents, Catheters, Dose-Response Relationship, drug, drug administration schedule, drug effects, drug therapy, female, Haemophilus Infections, Haemophilus influenzae, Indwelling
Division: Clinical Pharmacology and Pharmacometrics (CPP)

This study assessed daily aspirate samples from an indwelling sinus catheter during high-dose, short-course levofloxacin (750 mg daily x 5 days) treatment...

Pharmacodynamics of cefprozil against Haemophilus influenzae in an in vitro pharmacodynamic model

Pharmacodynamics of cefprozil against Haemophilus influenzae in an in vitro pharmacodynamic model

Authors: Smith PF, Tsuji B, Booker BM, Forrest A, Bajic S, Kelchlin P, Bhavnani SM, Jones RN, Ambrose PG
Publication: Diagn Microbiol Infect Dis
Keywords: anti-bacterial agents, cephalosporins, Dose-Response Relationship, drug, drug effects, drug therapy, growth & development, Haemophilus Infections, Haemophilus influenzae, humans, in vitro, methods, Microbial Sensitivity Tests, microbiology, otitis media
Division: Clinical Pharmacology and Pharmacometrics (CPP)

An in vitro pharmacodynamic model was used to determine the pharmacokinetic-pharmacodynamic (PK-PD) measure and magnitude most strongly related...

Population pharmacokinetics of risperidone and 9-hydroxyrisperidone in patients with acute episodes associated with bipolar I disorder

Population pharmacokinetics of risperidone and 9-hydroxyrisperidone in patients with acute episodes associated with bipolar I disorder

Authors: Vermeulen A, Piotrovsky V, Ludwig EA
Publication: J Pharmacokinet Pharmacodyn
Keywords: Acute Disease, administration, administration & dosage, adult, aged, antipsychotic agents, Bipolar Disorder, blood, body mass index, body weight, Carbamazepine, computer simulation, Creatinine, Cytochrome P-450 CYP2D6, Databases as Topic, Drug Admini, oral
Division: Clinical Pharmacology and Pharmacometrics (CPP)

A population model was developed with the aim to simultaneously describe risperidone and 9-hydroxyrisperidone pharmacokinetics; to obtain estimates for pharmacokinetic parameters and associated...

Selective activation of estrogen receptor-beta transcriptional pathways by an herbal extract

Selective activation of estrogen receptor-beta transcriptional pathways by an herbal extract

Authors: Cvoro A, Paruthiyil S, Jones JO, Tzagarakis-Foster C, Clegg NJ, Tatomer D, Medina RT, Tagliaferri M, Schaufele F, Scanlan TS, Diamond MI, Cohen I, Leitman DC
Publication: Endocrinology
Keywords: ERbeta-selective ligands, menopausal symptoms, Novel estrogenic therapies
Division: PBPK

Novel estrogenic therapies are needed that ameliorate menopausal symptoms and have the bone-sparing effects of endogenous estrogens but do not promote breast or...

In Silico Prediction of Ionization

In Silico Prediction of Ionization

Authors: Fraczkiewicz R
Publication: Comprehensive Medicinal Chemistry II, Vol. 5
Keywords: acid–base equilibrium, acidity, aqueous ionization, basicity, in silico prediction, ionization prediction, linear free energy relationships (LEFR), pKa, pKa prediction, quantitative structure–activity relationship (QSAR)
Software: ADMET Predictor®
Division: PBPK

The focus of this chapter is computational methods for the prediction of aqueous ionization of organic molecules.