Company's Structure-Property Prediction and Model-Building Software Programs Will Be Sold as a Complete Structure-Property Prediction and Modeling Package
Simulations Plus Receives Multo-Year Pharmaceutical Software License
Large Pharmaceutical Company Renews Multi-year License
Simulations Plus Releases GastroPlus(™) 5.1
Important New Improvements Added to the Company's Gold Standard Software
Simulations Plus Reports Second Quarter FY2006 Financial Results
Company Sets New Record for Second Quarter Revenues and Earnings
Simulations Plus Announces Second Quarter 2006 Earnings Conference Call
Conference Call to be on Thursday, April 13, at 4:15 PM EDT
Pharmacokinetic/Pharmacodynamic (PK/PD) Model for the Safety of Tigecycline (T) in Patients with Complicated Intra-Abdominal Infections (cIAI)
Nausea (N) and vomiting (V) have been reported with tigecycline, a new glycylcycline with expanded broad spectrum activity. 140 exposure-response relationships and patient covariates predictive of the first N…
NIPALSTREE: A New Hierarchical Clustering Approach for Large Compound Libraries and Its Application to Virtual Screening
A hierarchical clustering algorithm NIPALSTREE was developed that is able to analyze large data sets in high-dimensional space. The result can be displayed as a dendrogram.
Simulations Plus Releases ClassPharmer 4.0
Dramatic Improvements in Speed and Function Expected to Improve Drug Discovery
Mutational analysis of the varicella-zoster virus ORF62/63 intergenic region
The varicella-zoster virus (VZV) ORF62/63 intergenic region was cloned between the Renilla and firefly luciferase genes, which acted as reporters of ORF62 and ORF63...
Pharmacokinetic/pharmacodynamic (PK/PD) Model for Tolvaptan in Healthy Subjects
Direct effect, indirect effect, and competitive antagonism models were evaluated to describe plasma tolvaptan concentration effect on urine flow rate (UFR), with consideration of water intake rate (WIR)…
Pharmacokinetic-pharmacodynamic relationships describing the efficacy of oritavancin in patients with Staphylococcus aureus bacteremia
Bloodstream infections due to antimicrobial-resistant Staphylococcus aureus occur with increasing frequency and represent an important cause of morbidity and mortality.
Are Target-Family-Privileged Substructures Truly Privileged?
One of the early and effective approaches to G-coupled protein receptor target family library design was the analysis of a set of ligands for frequently occurring chemical moieties or substructures.
Assessing the Scaffold Diversity of Screening Libraries
Medicinal chemists have traditionally realized assessments of chemical diversity and subsequent compound acquisition, although a recent study suggests that experts are usually inconsistent in reviewing large data sets.
A strategy for preclinical formulation development using GastroPlus™ as pharmacokinetic simulation tool and a statistical screening design applied to a dog study.
The aim of this paper is to propose a pharmaceutical risk assessment strategy that goes beyond the usual characterisation of a clinical candidate molecule according to the biopharmaceutical classification system (BCS).
Simulation of Midazolam Absorption and Bioavailability in Pediatric Patients
To evaluate the accuracy of prediction of Midazolam absorption and bioavailability in a pediatric population from in silico, in vitro and adult in vivo data. The significance of scaling of the clearance and…
Comparison of censored regression and standard regression analyses for modeling relationships between antimicrobial susceptibility and patient- and institution-specific variables
In order to identify patients likely to be infected with resistant bacterial pathogens, analytic methods such as standard regression (SR) may be applied to surveillance data to determine patient- and institution-specific...
In Vitro Simulation Adinazolam Mesylate Swellable HPMC Matrix Release Using DDDPlus™ Software
Pharmaceutical systems containing a mixture of drug, excipients, and polymer can be used as effective controlled release formulations. The presence of drug and excipients in the polymer matrix creates a…
Simulations Plus Renews Important Global Software License
Large Customer Renews Annual Global License for GastoPlus ™
Population Pharmacokinetics of Tigecycline in Patients with Complicated Skin and Skin-Structure and Intra-Abdominal Infections
Tigecycline is a novel glycylcycline antibiotic with expanded broad-spectrum in vitro activity, including emerging multidrug-resistant pathogens. The goal of this analysis was to develop a PPK model for…