Living Tongues

Living Tongues

Languages, even seldom-used languages, can tell us a great deal about how a group of people categorize the natural and mental world, says Jeff Good, a linguistics professor at the State University of New York at Buffalo (1). Languages are rich in the history and taxonomy of a place, reflecting subtleties that can be lost in translation, says Greg Anderson, an ethnographer who directs Oregon’s Living Tongues Institute (2). When the last keepers of a language die off, so does the fluent understanding of that particular environment.

Non-competitive androgen receptor inhibition in vitro and in vivo

Non-competitive androgen receptor inhibition in vitro and in vivo

Publication: Proc Natl Acad Sci USA
Division: PBPK

Androgen receptor (AR) inhibitors are used to treat multiple human diseases, including hirsutism, benign prostatic hypertrophy, and prostate cancer, but all available...

Kerfuffle!

Kerfuffle!

Publication: J Clin Pharmacol

To become disheveled. A kerfuffle is the polite term for a cascading series of errors that can be initiated by a seemingly innocuous event that then leads to other...

How Jazz Hastened Civil Rights

How Jazz Hastened Civil Rights

Jazz had a largely unappreciated role in hastening the arrival of the civil rights movement, according to veteran jazz writer Nat Hentoff. As early as the 1920s, white and black jazz musicians played together in after-hours jam sessions. But it was not until the 1940s, Hentoff said in the January 15, 2009, issue of the Wall Street Journal, that jazz musicians and their audiences mixed publicly in clubs—tentatively at first, but then freely and openly, in violation of local laws and mores. As jazz captured more and more avid listeners, white Americans started to understand the effect of segregation in all aspects of American culture.

Development of a Steady-State Exposure-Response Model for Exenatide Once Weekly

Development of a Steady-State Exposure-Response Model for Exenatide Once Weekly

Conference: ASCPT

Exenatide is dosed as a subcutaneous (SC) injection of 5 and 10 μg twice daily (BID) before main meals and is indicated for the treatment of type 2 diabetes mellitus in patients failing to achieve adequate…

Dan Carlin’s Hardcore History

Dan Carlin’s Hardcore History

In Dan Carlin’s Hardcore History podcasts, the past is twisted and turned upside down in novel and intriguing ways. Dan Carlin, a veteran journalist and radio talk show host, emphasizes the drama of past events and personalities to reveal why history matters today.

Calculation of molecular lipophilicity: State-of-the-art and comparison of log P methods on more than 96,000 compounds

Calculation of molecular lipophilicity: State-of-the-art and comparison of log P methods on more than 96,000 compounds

Publication: J Pharm Sci
Software: ADMET Predictor®

We first review the state-of-the-art in development of log P prediction approaches falling in two major categories: substructure-based and property-based methods.

Application of patient population-derived pharmacokinetic-pharmacodynamic relationships to tigecycline breakpoint determination for staphylococci and streptococci

Application of patient population-derived pharmacokinetic-pharmacodynamic relationships to tigecycline breakpoint determination for staphylococci and streptococci

Correctly determined susceptibility breakpoints are important to both the individual patient and to society at large. A previously derived patient population...

Toward an In Vivo Dissolution Methodology: A Comparison of Phosphate and Bicarbonate Buffers

Toward an In Vivo Dissolution Methodology: A Comparison of Phosphate and Bicarbonate Buffers

Publication: Mol Pharm
Software: ADMET Predictor®

The purpose of this research was to evaluate the difference between the pharmaceutical phosphate buffers and the gastrointestinal bicarbonates in dissolution of ketoprofen and indomethacin...

Analysis of Risk Factors in Human Bioequivalence Study That Incur Bioinequivalence of Oral Drug Products

Analysis of Risk Factors in Human Bioequivalence Study That Incur Bioinequivalence of Oral Drug Products

Publication: Mol Pharm
Software: ADMET Predictor®

In the study of human bioequivalence (BE), newly developed oral products sometimes fail to prove BE with a reference product due to the high variability in pharmacokinetic (PK)...

Busting the Black Box Myth: Designing Out Unwanted ADMET Properties with Machine Learning Approaches

Busting the Black Box Myth: Designing Out Unwanted ADMET Properties with Machine Learning Approaches

Publication: CICSJ Bulletin
Software: ADMET Predictor®
Division: PBPK

Drug design is usually understood as “an inventive process of finding new medications based on the knowledge of the biological target” – according to the...