I found that I was getting into a musical rut and had a hard time finding new music I liked. Then I stumbled on Pandora Internet Radio. On Pandora, you create your own “radio station” by naming a favorite song or artist. Pandora scans thousands of pieces of music that have been analyzed by something called the Music Genome Project to identify those with similar attributes to the one you named. Voilà! New music for you to enjoy.
Simulations Plus Wins Phase II, Small Business Innovation Research Grant
$525,000 Grant to Speed Commercialization of Advancements to Company’s Industry-Leading Molecular Property Prediction Software
Simulations Plus Reports Second Quarter FY2009 Financial Results
Continued Growth – Revenues Up 12.7%, Cash Up 20.2%
Simulations Plus Sets Date for Second Quarter Fiscal Year 2009 Earnings Release and Conference Call
Conference Call to be on Wednesday, April 15, at 4:15 PM EDT
Living Tongues
Languages, even seldom-used languages, can tell us a great deal about how a group of people categorize the natural and mental world, says Jeff Good, a linguistics professor at the State University of New York at Buffalo (1). Languages are rich in the history and taxonomy of a place, reflecting subtleties that can be lost in translation, says Greg Anderson, an ethnographer who directs Oregon’s Living Tongues Institute (2). When the last keepers of a language die off, so does the fluent understanding of that particular environment.
Non-competitive androgen receptor inhibition in vitro and in vivo
Androgen receptor (AR) inhibitors are used to treat multiple human diseases, including hirsutism, benign prostatic hypertrophy, and prostate cancer, but all available...
Kerfuffle!
To become disheveled. A kerfuffle is the polite term for a cascading series of errors that can be initiated by a seemingly innocuous event that then leads to other...
How Jazz Hastened Civil Rights
Jazz had a largely unappreciated role in hastening the arrival of the civil rights movement, according to veteran jazz writer Nat Hentoff. As early as the 1920s, white and black jazz musicians played together in after-hours jam sessions. But it was not until the 1940s, Hentoff said in the January 15, 2009, issue of the Wall Street Journal, that jazz musicians and their audiences mixed publicly in clubs—tentatively at first, but then freely and openly, in violation of local laws and mores. As jazz captured more and more avid listeners, white Americans started to understand the effect of segregation in all aspects of American culture.
Development of a Steady-State Exposure-Response Model for Exenatide Once Weekly
Exenatide is dosed as a subcutaneous (SC) injection of 5 and 10 μg twice daily (BID) before main meals and is indicated for the treatment of type 2 diabetes mellitus in patients failing to achieve adequate…
Dan Carlin’s Hardcore History
In Dan Carlin’s Hardcore History podcasts, the past is twisted and turned upside down in novel and intriguing ways. Dan Carlin, a veteran journalist and radio talk show host, emphasizes the drama of past events and personalities to reveal why history matters today.
Predicting pharmacokinetics of drugs using physiologically based modeling – application to food effects
Our knowledge of the major mechanisms underlying the effect of food on drug absorption allows reliable qualitative prediction based on biopharmaceutical properties...
Modelling and PBPK Simulation in Drug Discovery
Physiologically based pharmacokinetic (PBPK) models are composed of a series of differential equations and have been implemented in a number of commercial...
Calculation of molecular lipophilicity: State-of-the-art and comparison of log P methods on more than 96,000 compounds
We first review the state-of-the-art in development of log P prediction approaches falling in two major categories: substructure-based and property-based methods.
Kerfuffle! (pt 2)
Chapter 2 of 3. Need to catch up? Read the previous post in the series.
Application of patient population-derived pharmacokinetic-pharmacodynamic relationships to tigecycline breakpoint determination for staphylococci and streptococci
Correctly determined susceptibility breakpoints are important to both the individual patient and to society at large. A previously derived patient population...
Toward an In Vivo Dissolution Methodology: A Comparison of Phosphate and Bicarbonate Buffers
The purpose of this research was to evaluate the difference between the pharmaceutical phosphate buffers and the gastrointestinal bicarbonates in dissolution of ketoprofen and indomethacin...
Simulations Plus Reports First Quarter FY2009 Financial Results
Company Sets New Record for First Quarter: Revenues up 7.5% and Earnings Up Over 28%
Simulations Plus Sets Date for First Quarter Fiscal Year 2008 Earnings Release and Conference Call
Conference Call to be on Thursday, January 15, at 4:15 PM EST
Simulations Plus Releases ClassPharmer™ Version 4.6
New Version Further Improves Powerful Data Mining and Drug Design Capabilities
Justification of biowaiver for carbamazepine, a low soluble high permeable compound, in solid dosage forms based on IVIVC and gastrointestinal simulation
The aim of the present study was to use gastrointestinal simulation technology and in vitro-in vivo correlation (IVIVC) as tools to investigate a possible extension of biowaiver criteria...