Robots

Robots

Take a look at BigDog and his amazing robot pals in this link to the New York Times. Or, if you love cute and cuddly, you should check out Paro.

World (Cup) Cultures

World (Cup) Cultures

One of the true pleasures of my job is the opportunity to travel and meet people from all over the world. Different cultures presume different business and social behaviors, of course.* But I have found that in spite of the differences, there are at least two similarities among world cultures: a passion to cheer for your national team to win the World Cup and a nearly universal reviling of the vuvuzelas.

Life’s Too short

Life’s Too short

In a recent Wall Street Journal column, Terry Teachout had a wonderful essay questioning the complexity of modern art.* He quotes from James Joyce’s Finnegans Wake, which contains sentences like this:

Physiologically-Based Pharmacokinetic (PBPK) Modeling of Diltiazem-Midazolam Drug-Drug Interaction (DDI)

Physiologically-Based Pharmacokinetic (PBPK) Modeling of Diltiazem-Midazolam Drug-Drug Interaction (DDI)

Conference: DDI
Division: PBPK

The purpose of this modeling effort was to explore the effects of various processes and physiological parameters on the DDI involving competitive and time-dependent inhibition (TDI). Absorption and…

Single-Dose And Steady-State Pharmacokinetics Of Moxduo™, A Dual-Opioid Formulation Containing A Fixed Ratio Of Morphine And Oxycodone

Single-Dose And Steady-State Pharmacokinetics Of Moxduo™, A Dual-Opioid Formulation Containing A Fixed Ratio Of Morphine And Oxycodone

Conference: American Pain Society (APS)

Q8003 (MoxDuo™) is the first dual-opioid combination product that has been evaluated in clinical trials. MoxDuo immediate-release capsules were developed for the management of acute moderate to severe…

Mesmerizing Machine

Mesmerizing Machine

As you study the blue ball machine, it is easy to see how you can be mesmerized by a process that doesn’t actually do anything. See if you can find the part where the ball replaces the worker’s head. Then find the little sign that every now and then flashes NO. It never says yes

Disambiguation

Disambiguation

I first came across the word “disambiguation” at a weekend workshop called Ontology in Science. (There is so much that’s just wrong about what I just admitted, but never mind.) I like this word a lot because it makes people ask, “for goodness sake, what are you talking about?” But disambiguation is a serious word, especially in science. It means “to remove ambiguity.” Once you learn that there is a word for getting rid of ambiguity, you begin to realize how much ambiguity there is in the world, especially when people communicate. And it seems to me that the smarter the people and the more complex the topic, the more disambiguation is necessary.

Semi-mechanistic PK/PD Model of the Effect of Odanacatib, a Cathepsin K Inhibitor, on Bone Turnover to Characterize Lumbar Spine Bone Mineral Density in Two Phase II Studies of Postmenopausal Women

Semi-mechanistic PK/PD Model of the Effect of Odanacatib, a Cathepsin K Inhibitor, on Bone Turnover to Characterize Lumbar Spine Bone Mineral Density in Two Phase II Studies of Postmenopausal Women

Conference: International Symposium on Measurement and Kinetics of in vivo Drug Effects

Odanacatib (MK-0822), a potent, orally-active inhibitor of cathepsin K, is under clinical development for treatment of postmenopausal osteoporosis. This poster describes base model development of a…