In the lead optimization process, medicinal chemists must consider various chemical properties of active compounds, including ADME/Tox properties, and find the best compromise among these.
![Simulations Plus Reports First Quarter FY2008 Financial Results](https://www.simulations-plus.com/wp-content/themes/simulations-plus/library/dist/img/default_square-large.jpg)
Simulations Plus Reports First Quarter FY2008 Financial Results
Revenues Increase 36%, Earnings Increase 232%
![A critical evaluation of fasted state simulating gastric fluid (FaSSGF) that contains sodium lauryl sulfate and proposal of a modified recipe.](https://www.simulations-plus.com/wp-content/themes/simulations-plus/library/dist/img/default_square-large.jpg)
A critical evaluation of fasted state simulating gastric fluid (FaSSGF) that contains sodium lauryl sulfate and proposal of a modified recipe.
The aim of this work is to evaluate one of the most commonly used fasted state simulating gastric fluids (FaSSGFs), which contains sodium lauryl sulfate (SLS) (FaSSGFSLS), and propose a more appropriate...
![Exposure response analyses of tigecycline efficacy in patients with complicated intra-abdominal infections](https://www.simulations-plus.com/wp-content/themes/simulations-plus/library/dist/img/default_square-large.jpg)
Exposure response analyses of tigecycline efficacy in patients with complicated intra-abdominal infections
Exposure-response analyses were performed to test the microbiological and clinical efficacies of tigecycline in complicated intra-abdominal infections where...
![Design and implementation of cell-based assays to model human disease](https://www.simulations-plus.com/wp-content/themes/simulations-plus/library/dist/img/default_square-large.jpg)
Design and implementation of cell-based assays to model human disease
Cell-based assays, if appropriately designed, can be used to rapidly identify molecular mechanisms of human disease and develop novel therapeutics. In the last 20 years...
![PK/PD Modeling of Adinazolam](https://www.simulations-plus.com/wp-content/themes/simulations-plus/library/dist/img/default_square-large.jpg)
PK/PD Modeling of Adinazolam
Develop a model for prediction of the pharmacokinetic (PK) and pharmacodynamic (PD) profiles of Adinazolam from IV, immediate release oral, and controlled release oral formulations.
![Influence Of Estimation Of Inter-Occasion Variability On Detection Of Time-Varying Covariates](https://www.simulations-plus.com/wp-content/themes/simulations-plus/library/dist/img/default_square-large.jpg)
Influence Of Estimation Of Inter-Occasion Variability On Detection Of Time-Varying Covariates
To explore the influence of the estimation of inter-occasion variability (IOV) on the ability to detect time-varying covariates influencing PK parameters from a population PK (PPK) analysis using NONMEM.
![Plasma Pharmacokinetic (PK) Profile of Two Consecutive Doses of Ferumoxytol in Healthy Subjects](https://www.simulations-plus.com/wp-content/themes/simulations-plus/library/dist/img/default_square-large.jpg)
Plasma Pharmacokinetic (PK) Profile of Two Consecutive Doses of Ferumoxytol in Healthy Subjects
Ferumoxytol is a carbohydrate-coated superparamagnetic iron oxide nanoparticle being evaluated for safety and efficacy in two distinct areas of medical need.
![Prediction of Log P with Property‐Based Methods](https://www.simulations-plus.com/wp-content/themes/simulations-plus/library/dist/img/default_square-large.jpg)
Prediction of Log P with Property‐Based Methods
This first systematic overview for more than a decade is tailor-made for the medicinal chemist.
![Simulations Plus Releases Major Upgrade To GastroPlus(™) Software](https://www.simulations-plus.com/wp-content/themes/simulations-plus/library/dist/img/default_square-large.jpg)
Simulations Plus Releases Major Upgrade To GastroPlus(™) Software
Version 5.3 Further Enhances Industry's Gold Standard Product
![Prediction of Human Pharmacokinetics Using Physiologically Based Modeling: A Retrospective Analysis of 26 Clinically Tested Drugs](https://www.simulations-plus.com/wp-content/themes/simulations-plus/library/dist/img/default_square-large.jpg)
Prediction of Human Pharmacokinetics Using Physiologically Based Modeling: A Retrospective Analysis of 26 Clinically Tested Drugs
The aim of this study was to evaluate different physiologically based modeling strategies for the prediction of human pharmacokinetics.
![Population pharmacokinetic meta-analysis of trabectedin (ET-743, Yondelis) in cancer patients](https://www.simulations-plus.com/wp-content/themes/simulations-plus/library/dist/img/default_square-large.jpg)
Population pharmacokinetic meta-analysis of trabectedin (ET-743, Yondelis) in cancer patients
To characterise the population pharmacokinetics of trabectedin (ET-743, Yondelis(R)) in cancer patients.
![Population pharmacokinetics of (R)-albuterol and (S)-albuterol in pediatric patients aged 4-11 years with asthma](https://www.simulations-plus.com/wp-content/themes/simulations-plus/library/dist/img/default_square-large.jpg)
Population pharmacokinetics of (R)-albuterol and (S)-albuterol in pediatric patients aged 4-11 years with asthma
To characterize the population pharmacokinetics (PK) of (R)- and (S)-albuterol in pediatric asthmatics using a model that supports a sparse blood sampling strategy.
![Experienced Formulation Scientist Becomes Director of Life Sciences](https://www.simulations-plus.com/wp-content/themes/simulations-plus/library/dist/img/default_square-large.jpg)
Experienced Formulation Scientist Becomes Director of Life Sciences
Dr. John Crison Joins Simulations Plus
![Simulations Plus and Enslein Research Sign Agreement](https://www.simulations-plus.com/wp-content/themes/simulations-plus/library/dist/img/default_square-large.jpg)
Simulations Plus and Enslein Research Sign Agreement
Prediction of Metabolism from Important Group of Enzymes to be Added to ADMET Predictor™
![Simulations Plus Reports Fourth Quarter and Fiscal Year 2007 Preliminary Revenues](https://www.simulations-plus.com/wp-content/themes/simulations-plus/library/dist/img/default_square-large.jpg)
Simulations Plus Reports Fourth Quarter and Fiscal Year 2007 Preliminary Revenues
Another New Record Set for Quarterly and Annual Revenues
![U.S. National Institutes of Health Licenses Simulations Plus’ ClassPharmer™ Software](https://www.simulations-plus.com/wp-content/themes/simulations-plus/library/dist/img/default_square-large.jpg)
U.S. National Institutes of Health Licenses Simulations Plus’ ClassPharmer™ Software
Another Government Agency Licenses Key Software Product
![U.S. FDA Expands Simulations Plus Software Licenses](https://www.simulations-plus.com/wp-content/themes/simulations-plus/library/dist/img/default_square-large.jpg)
U.S. FDA Expands Simulations Plus Software Licenses
GastroPlus and DDDPlus Licenses Added