Physiologically based pharmacokinetic (PBPK) modeling tools have become an integral part of the modern drug discovery−development process.
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Robots
Take a look at BigDog and his amazing robot pals in this link to the New York Times. Or, if you love cute and cuddly, you should check out Paro.
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Simulations Plus Reports Third Quarter FY2010 Financial Results
Another Record Quarter with Revenues up 15% and Earnings up 30% over Last Year’s Q3
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World (Cup) Cultures
One of the true pleasures of my job is the opportunity to travel and meet people from all over the world. Different cultures presume different business and social behaviors, of course.* But I have found that in spite of the differences, there are at least two similarities among world cultures: a passion to cheer for your national team to win the World Cup and a nearly universal reviling of the vuvuzelas.
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Life’s Too short
In a recent Wall Street Journal column, Terry Teachout had a wonderful essay questioning the complexity of modern art.* He quotes from James Joyce’s Finnegans Wake, which contains sentences like this:
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Simulations Plus Reports Preliminary Revenues for Third Fiscal Quarter of FY2010
New Record Quarter of $3.1 Million Due to Sustained Growth in Revenues
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Sense and Sensibilities of Science
If you want to understand process formalization, read Jane Austen.
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Forensic Pharmacometrics: Part 2 – Deliverables for Regulatory Submission
As modeling and simulation results become increasingly integral to critical development-related decision-making and program outcomes, the consequences of poor documentation of pharmacometric analyses can…
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Rationalizing the development of live attenuated virus vaccines
The design of vaccines against viral disease has evolved considerably over the past 50 years. Live attenuated viruses (LAVs)-those created by passaging a virus in cultured...
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Physiologically-Based Pharmacokinetic (PBPK) Modeling of Diltiazem-Midazolam Drug-Drug Interaction (DDI)
The purpose of this modeling effort was to explore the effects of various processes and physiological parameters on the DDI involving competitive and time-dependent inhibition (TDI). Absorption and…
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SLP Subsidiary Words+ Launches EyePro™ System
New System Enables Users to Operate Computer Simply by Looking at It
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Single-Dose And Steady-State Pharmacokinetics Of Moxduo™, A Dual-Opioid Formulation Containing A Fixed Ratio Of Morphine And Oxycodone
Q8003 (MoxDuo™) is the first dual-opioid combination product that has been evaluated in clinical trials. MoxDuo immediate-release capsules were developed for the management of acute moderate to severe…
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Mesmerizing Machine
As you study the blue ball machine, it is easy to see how you can be mesmerized by a process that doesn’t actually do anything. See if you can find the part where the ball replaces the worker’s head. Then find the little sign that every now and then flashes NO. It never says yes
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Disambiguation
I first came across the word “disambiguation” at a weekend workshop called Ontology in Science. (There is so much that’s just wrong about what I just admitted, but never mind.) I like this word a lot because it makes people ask, “for goodness sake, what are you talking about?” But disambiguation is a serious word, especially in science. It means “to remove ambiguity.” Once you learn that there is a word for getting rid of ambiguity, you begin to realize how much ambiguity there is in the world, especially when people communicate. And it seems to me that the smarter the people and the more complex the topic, the more disambiguation is necessary.
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Semi-mechanistic PK/PD Model of the Effect of Odanacatib, a Cathepsin K Inhibitor, on Bone Turnover to Characterize Lumbar Spine Bone Mineral Density in Two Phase II Studies of Postmenopausal Women
Odanacatib (MK-0822), a potent, orally-active inhibitor of cathepsin K, is under clinical development for treatment of postmenopausal osteoporosis. This poster describes base model development of a…
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Simulations Plus Reports Second Quarter FY2010 Financial Results
Sustained Growth in Record Second Quarter and Record First Six Months
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Simulations Plus Sets Date for 2nd Quarter Fiscal Year 2010 Earnings Release and Conference Call
Conference Call to be on Thursday, April 15, at 12:00 noon EDT