String of Record Quarters Sustains Multi-Year Growth Trend

Simulations Plus (“SLP”) Releases ADMET Predictor Version 5.5
New Predictions Further Extend Best-in-Class Software

Simulations Plus (“SLP”) Launches MedChem Designer
Powerful Molecule Drawing Tool Added to World-Class Product Line

Use of structure-activity landscape index curves and curve integrals to evaluate the performance of multiple machine learning prediction models
Standard approaches to address the performance of predictive models that used common statistical measurements for the entire data set provide an overview of...

Simulations Plus to Collaborate with FDA to Develop Predictive Toxicity Models
Center for Food Safety and Applied Nutrition (CFSAN) to Provide Data

So, how cold was it?
We’ve had a cold winter so far in the USA, don’t you think? Snow in Alabama, a blizzard in Boston, another in Chicago, an ice storm in Dallas before the Super Bowl. . .Yep, it’s cold outside. But, take a look at this picture from 100 years ago. It’s hard to imagine how cold it had to have been to make Niagara Falls freeze over.

Simulations Plus Reports First Quarter FY2011 Financial Results
Pharmaceutical Software and Services Revenues Up 18%, Words+ Subsidiary Up 8.3%, Consolidated Earnings Up 32%, and EPS Up 34% from 1QFY10

Simulations Plus Sets Date for 1st Quarter 2011 Earnings Release and Conference Call
Conference Call to be on Friday, January 14, at 11:00 AM EST

A short tour of the universe.
If you want a cheap but out-of-this-world vacation, a short tour of the universe may be just what you are looking for. This video was posted by Adam Frank last January on a National Public Radio blog called 13.7: Cosmos and Culture.

Evolving hERG Inhibition Model
Modeling hERG inhibition has significantly gained popularity since 2005, when the FDA recognized the correlation between hERG inhibition and a prolonged QT interval by issuing guidance for the…

Physiologically-Based Pharmacokinetic (PBPK) Model for Prediction of Tobramycin Pulmonary Absorption and Pharmacokinetics in Children
To fit an absorption-pharmacokinetic model for simulation of tobramycin in adult and pediatric populations. Tobramycin pulmonary absorption and pharmacokinetics were simulated using GastroPlus™.

Physiologically-based pharmacokinetic {PBPK) models for prediction of time-dependent enzyme inhibition (TDI): effect of diltiazem on midazolam and quinidine
Purpose of the study was to optimize a PBPK model to predict timedependent and competitive inhibition of CYP 3A4 by diltiazem...

Pharmacokinetics of dietary cancer chemopreventive compound dibenzoylmethane in rats and the impact of nanoemulsion and genetic knockout of Nrf2 on its disposition
The pharmacokinetic disposition of a dietary cancer chemopreventive compound dibenzoylmethane (DBM) was studied in male Sprague-Dawley rats after intravenous...

Impressions of Monet.
I recently had the occasion to visit the Monet exhibition at the Grand Palais in Paris. Several things about this exhibit blew me away.

New Graph Library
A new graph library that provides the right graphs at the right time and with the right information has been developed by Cognigen Corporation, a leading provider of pharmacometric analysis and support services. Comprehensive graphical exploratory data analysis is essential to building pharmacometric models of drug behavior. Previously, deciding which graphs were required to describe the data and then creating a new program for each graph consumed excessive time from both scientists and programmers.

Trends in kinase selectivity: insights for target class-focused library screening
A kinome-wide selectivity screen of >20000 compounds with a rich representation of many structural classes has been completed.

Simulations Plus Reports Preliminary Revenues for First Fiscal Quarter of FY2011
Record First Quarter and Sustained Multi-year Growth Trend

Simulations Plus Reports FY2010 and Fourth Quarter FY2010 Financial Results
Fiscal Year Earnings Jump 52.7% on 17.2% Revenue Increase

Simulations Plus Sets Date for 4 th Quarter and Fiscal Year 2010 Earnings Release and Conference Call
Conference Call to be on Tuesday, November 30, at 4:15 PM EST

Learning to be an architect of ideas.
I have long been addicted to The New York Times Book Review. It is not that I am a writer groupie as much as I find it fascinating to read about how a book came about.