Scientific workflows – the knowledge-generating engines of R&D.

Scientific workflows – the knowledge-generating engines of R&D.

Scientific research requires two kinds of effort. One is the generation and synthesis of original ideas by skilled practitioners. This is a desirable and often lauded talent that can spawn remarkable innovations in science and medical care. The second kind of effort is less visible, but equally important—the hard work required to turn an idea into reality. Executing the experiments, analyzing the data, and developing presentations of results are examples of this work. Although these latter efforts are necessary, and even enjoyable, they nonetheless can be tedious, time-consuming, and expensive.

Mixture Modeling as a Data Imputation Method

Mixture Modeling as a Data Imputation Method

Conference: ACoP

To demonstrate the use of mixture modeling in population PK analysis to predict drug concentrations for a subset of subjects with missing data for a key categorical covariate.

Productivity is not a four letter word.

Productivity is not a four letter word.

For me, anyway, the point of opinion writing is less to try to shape events, a presumptuous and foolhardy ambition at best, than to help stimulate debate and, from my particular perspective, try to explain why things got the way they are and what they might mean and where they might lead. My own idiosyncratic bent as a writer, no doubt a legacy of my years spent in the theater, is to look for a narrative in the many competing dramas unfolding on the national stage.

Frank Rich, New York Times

Astronomy picture of the day.

Astronomy picture of the day.

During the time that I was a clinical pharmacology fellow with Lewis Sheiner and Stuart Beal in San Francisco, the Voyager mission [1] was sending back incredible images of the moons of Jupiter and the rings of Saturn.

New to an Organization: Tools to Assess Projects and Teams

New to an Organization: Tools to Assess Projects and Teams

Conference: Project Management Institute (PMI) Pharmaceutical Community of Practice (CoP)

The complexity of project management and its value increase exponentially as the number and complexity of projects and interdisciplinary team participation increases.

Exposure–Response Analysis of Eslicarbazepine Acetate as Adjunctive Treatment of Patients With Partial-onset Seizures

Exposure–Response Analysis of Eslicarbazepine Acetate as Adjunctive Treatment of Patients With Partial-onset Seizures

Conference: ASCPT

Eslicarbazepine acetate (ESL) is a novel once-daily (QD) antiepileptic drug (AED) currently under clinical development in the US. ESL is rapidly and extensively metabolized to its major active metabolite…

Population Pharmacokinetics of Eslicarbazepine Acetate in Patients With Partial-onset Seizures

Population Pharmacokinetics of Eslicarbazepine Acetate in Patients With Partial-onset Seizures

Conference: ASCPT

Eslicarbazepine acetate (ESL) is a novel once-daily antiepileptic drug (AED) currently under clinical development in the US. Following oral administration, ESL is rapidly and extensively metabolized…

In Vitro-In Vivo Correlation for Gliclazide Immediate-Release Tablets Based on Mechanistic Absorption Simulation.

In Vitro-In Vivo Correlation for Gliclazide Immediate-Release Tablets Based on Mechanistic Absorption Simulation.

Publication: AAPS PharmSciTech
Software: GastroPlus®

The aim of this study was to develop a drug-specific absorption model for gliclazide (GLK) using mechanistic gastrointestinal simulation technology (GIST) implemented...

Computers win on Oscar night.

Computers win on Oscar night.

Did you watch the Oscars? A year ago, the 3D blockbuster, Avatar, was denied the Oscar for best film, which went to a low-budget war movie called The Hurt Locker. However, Avatar did win 3 Oscars in technical categories: Cinematography, Art Direction, and Visual Effects.