Every early compound candidate screening tool should neglect toxicity aspects.
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To improve health through innovative solutions.
AP Physicochemical & Biopharmaceutical (PCB) Module Flyer
ADMET Predictor® property prediction and QSAR model-building application
AP MedChem Studio™ Module Flyer
MedChem Studio is now free of charge for all our users for extended data analysis capabilities.
DNDI-6174 is a preclinical candidate for visceral leishmaniasis that targets the cytochrome bc
New drugs for visceral leishmaniasis that are safe, low cost, and adapted to the field are urgently required.
Evaluating the Role of N-Acetyl-L-Tryptophan in the Aβ 1-42-Induced Neuroinflammation and Cognitive Decline in Alzheimer’s Disease
Alzheimer’s disease (https://www.simulations-plus.com/wp-admin/post.php?post=35654&action=editAD), a neurodegenerative condition previously known to affect the older population, is also now seen in younger individuals.
Creating Quality by Committing to Compliance in Clinical Research
In the highly regulated world of clinical research, compliance is an ongoing concern, but can be viewed as an annoying and costly item to check off a regulatory to-do list.
Physiologically Based Pharmacokinetic Modeling in Neonates: Current Status and Future Perspectives
Rational drug use in special populations is a clinical problem that doctors and pharma-cists must consider seriously.
Log D7.4 and plasma protein binding of synthetic cannabinoid receptor agonists and a comparison of experimental and predicted lipophilicity
The emergence of new synthetic cannabinoid receptor agonists (SCRAs) onto the illicit drugs market continues to cause harm, and the overall availability of physicochemical and pharmacokinetic data for new psychoactive substances is lacking.
QSP Ulcerative Colitis (UC) Model Flyer
Quantitative Systems Pharmacology (QSP)
Ulcerative Colitis Model
QSP Systemic Lupus Erythematosus (SLE) Model Flyer
Quantitative Systems Pharmacology (QSP)
Systemic Lupus Erythematosus Model
QSP Rheumatoid Arthritis (RA) Model Flyer
Quantitative Systems Pharmacology (QSP)
Rheumatoid Arthritis Model
QSP Psoriatic Arthritis Model Flyer
Quantitative Systems Pharmacology (QSP)
Psoriatic Arthritis Model
QSP Psoriasis Model Flyer
Quantitative Systems Pharmacology (QSP)
Psoriasis Model
QSP Crohn’s Disease (CD) Model Flyer
Quantitative Systems Pharmacology (QSP)
Crohn’s Disease (CD) Model
QSP Atopic dermatitis Model Flyer
Quantitative Systems Pharmacology (QSP)
Atopic dermatitis Model
December 2023 News/Events
Fully Power Your First-in-Human Predictions
Role of Physiologically Based Biopharmaceutics Modeling (PBBM) in Fed Bioequivalence Study Waivers: Regulatory Outlook, Case Studies and Future Perspectives
Over the past few decades, physiologically based biopharmaceutics modeling (PBBM) has demonstrated its utility in both new drug and generic product development.
In silico prediction of bioequivalence of atorvastatin tablets based on GastroPlus™ software
The prediction of intestinal absorption of various drugs based on computer simulations has been a reality.
Cross species extrapolation of the disruption of thyroid hormone synthesis by oxyfluorfen using in vitro data, physiologically based pharmacokinetic (PBPK), and thyroid hormone kinetics models
The thyroid hormones play key roles in physiological processes such as regulation of the metabolic and cardiac systems as well as the development of the brain and surrounding sympathetic nervous system.