The Ocular Compartmental Absorption & Transit (OCAT™) model represents the eye as a collection of the following compartments: pre-cornea, cornea, conjunctiva, aqueous humor, iris-ciliary body, choroid-RPE, retina, sclera and vitreous humor.
GP ADR-Oral Cavity Module Flyer
The Oral Cavity Compartmental Absorption & Transit (OCCAT™) model represents the oral cavity (mouth) as a collection of the following compartments: buccal, gingival, palate, top of the tongue, bottom of the tongue, and mouth floor.
GP ADR-Pulmonary Module Flyer
The Pulmonary Compartmental Absorption & Transit (PCAT™) model represents the lung/nose as a collection of the following compartments: an optional nose, extra-thoracic, thoracic, bronchiolar and alveolar-interstitial.
GP Biologics Module Flyer
We are pleased to offer PBPK models for large molecules (biologics)
GP IVIVCPlus™ Module Flyer
GastroPlus® PBPK & PBBM was the first software program to offer “mechanistic deconvolutions”.
GP Metabolism & Transporter Module Flyer
The Metabolism and Transporter Module in GastroPlus® calculates Michaelis-Menten rates for gut and liver (or any PBPK tissue) metabolism and for carrier-mediated transport (influx or efflux – again, for any tissue in a PBPK model) based on input values for Vmax and Km.
GP Optimization Module Flyer
The Optimization Module performs the multidimensional search needed to fit model parameters to one or more data sets automatically.
GP PBPKPlus™ Module Flyer
Ranked as the #1 PBPK software for In Vitro-In Vivo Extrapolation (IVIVE) & PBPK modeling by Pfizer!
GP PDPlus™ Module Flyer
Automated model selection – fit across all direct, indirect, phase-nonspecific cell killing, bacteria killing PD models with a single mouse click to extend your PBPK models in GastroPlus® and easily find relationships between the pharmacodynamics and pharmacokinetics of your compound using plasma and/or tissue concentration profiles!
December 2023 GastroPlus Newsletter
GastroPlus® Newsletter December 2023
Novel application of PBBM to justify impact of faster dissolution on safety and pharmacokinetics – a case study and utility in regulatory justifications
Physiologically based biopharmaceutics modelling (PBBM) was recognised as potential approach for biopharmaceutics applications.
The Complexity of Bariatric Patient’s Pharmacotherapy: Sildenafil Biopharmaceutics and Pharmacokinetics before vs. after Gastric Sleeve/Bypass
Postbariatric altered gastrointestinal (GI) anatomy/physiology may significantly harm oral drug absorption and overall bioavailability.
AP Metabolism Module Flyer
Metabolism plays a critical role in the bioavailability of drugs, food additives, agrochemicals, and industrial chemicals.
AP High-throughput Pharmacokinetic (HTPK) Simulation Module Flyer
ADMET Predictor® property prediction and QSAR model-building application
AP AI-Driven Drug Design (AIDD) Module Flyer
Drug Design... Meet PBPK!
AP ADMET Modeler™ Module Flyer
ADMET Modeler is a QSAR/QSPR model building module in ADMET Predictor®.
AP Toxicity Module Flyer
Every early compound candidate screening tool should neglect toxicity aspects.
Vision, Mission and Values
To improve health through innovative solutions.
AP Physicochemical & Biopharmaceutical (PCB) Module Flyer
ADMET Predictor® property prediction and QSAR model-building application
AP MedChem Studio™ Module Flyer
MedChem Studio is now free of charge for all our users for extended data analysis capabilities.