Drug metabolism plays a crucial role in understanding bioavailability and drug-drug interactions, as well as in the design of prodrugs and in avoiding undesirable toxic metabolites.
Circadian Variations in Exsorptive Transport: In Situ Intestinal Perfusion Data and In Vivo Relevance
The circadian timing system (CTS) governs the 24-h rhythm of the organism and, hence, also main pathways responsible for drug pharmacokinetics.
Simulations Plus Announces Further Success in Malaria Drug Design Project
Activity Seen Against Both Drug-Sensitive and Drug-Resistant Strains
Simulations Plus Reports Second Quarter and First Six Months FY2012 Financial Results
Net sales increase 6.4% to record for any quarter of $2.789 million; first half net income up 22.7% to $1.810 million
Simulations Plus Sets Date for 2nd Quarter 2012 Earnings Release and Conference Call
Conference Call to Be on Tuesday, April 10, at 4:15 PM ET
MAA Found Math
Each week, the Mathematical Association of America website posts a new math-related photo that was submitted by an MAA member. The photo reposted here is a decorative Venn Diagram on a ceiling light that was featured on May 31, 2011. The photographer was Joy Hsiao of Brooklyn Technical High School. Visit the MAA Found Math gallery to view more of these fascinating photos.
Simulations Plus Announces Preliminary Success in Malaria Drug Design Project
New Molecule Has Excellent Activity Against Malaria Parasite
Modeling of Furosemide in DILIsym™ Model Reveals Testable Hypotheses about Hepatotoxicity Mechanisms
A predictive, quantitative, mathematical model (DILIsym™) is under development as a public-private initiative based on the physiological processes involved in drug-induced liver injury. The model includes…
Simulations Plus Buys out Royalty Agreement
Company Now Owns IP in ADMET Predictor™ Enslein Metabolism Module
In Silico Modeling for the Nonlinear Absorption Kinetics of UK-343,664: A P-gp and CYP3A4 Substrate
The aim of this work was to extrapolate in vitro and preclinical animal data to simulate the pharmacokinetic parameters of UK-343,664, a P-glycoprotein (P-gp) and CYP3A4 substrate, in human.
Simulations Plus Reports Record Second Quarter FY2012 Preliminary Revenues
Net sales increase to new record for any quarter of $2.789 million, up 24% sequentially and 6.4% compared to 2QFY11
Simulations Plus Announces Changes in Board of Directors
Dr. David Ralph, Professor of Marketing at Pepperdine University, to Replace Dr. Richard Weiss, Retiring after Nearly 15 Years on Board
The pluses and minuses of groupthink
Susan Cain recently wrote about the advantages and limitations of team work versus going it alone in the New York Times Sunday Review.
Small-molecule inhibitors of the androgen receptor
The present invention provides a method of inhibiting an androgen receptor by administering a compound of Formula I: or a compound of Formula II: wherein R1, R2, R3 and...
Provisional Biopharmaceutical Classification of Some Common Herbs Used in Western Medicine
The aim of this study was to classify some markers of common herbs used in Western medicine according to the Biopharmaceutical Classification System (BCS).
Simulations Plus Announces Cash Dividend
Board of directors declares an ongoing quarterly dividend of $0.05 per share
Thinking about thinking.
In a podcast called Thinking About Thinking, three eminent scientists discuss the ways humans think. All three have interesting and useful insights. I recommend this podcast to anyone responsible for managing Pharma R&D teams or for anyone looking for new ways to improve team performance, especially in knowledge-intensive research efforts.
George Steiner, a certain idea of knowledge.
George Steiner:
Our world is shrinking. Science is becoming inaccessible to us. Who can understand the latest innovations in genetics, astrophysics and biology? Who can explain them to the profane? Knowledge no longer communicates; writers and philosophers in our day are incapable of enabling us to understand science. At the same time, the scope of imagination in science is dazzling. How can we claim to speak of human consciousness if we overlook what is most daring and imaginative? I am concerned by what it means to be literate today. Is it possible to be literate if you do not understand non-linear equations?
Simulations Plus Reports First Quarter FY2012 Financial Results
Net sales increase 9.6% to first quarter record $2.248 million; Net income up 30.9% to $755,000