Cytochrome P450 3A4 (CYP3A4) is a member of the CYP family and is an important enzyme in drug metabolism.
Simulations Plus Reports First Quarter FY2013 Financial Results
Net sales increase 1.9% to first-quarter record $2.290 million; Earnings per share $0.04
I don’t understand why you don’t agree with me.
A New York Times* online essay by Gary Gutting, a philosophy professor, contains one of the clearest explanations of the differences between inductive and deductive reasoning I have seen.
Use of In Vitro-In Vivo Correlation to Predict the Pharmacokinetics of Several Products Containing a BCS Class 1 Drug in Extended Release Matrices
To determine if an IVIVC model can predict PK profiles of varying formulations of a BCS Class 1 drug that is a salt of a weak base.
Case Studies for Practical Food Effect Assessments across BCS/BDDCS Class Compounds using In Silico, In Vitro, and Preclinical In Vivo Data
Practical food effect predictions and assessments were described using in silico, in vitro, and/or in vivo preclinical data to anticipate food effects...
Structure-Activity-Selectivity Relations on the Keto-Pyrrolyl-Difluorophenol Aldose Reductase Inhibitory Scaffold
In recent years it has been observed worldwide a striking increase of cases of diabetes mellitus, which tend to attain an epidemic prevalence.
MembranePlus™: A Tool to Study in vitro/in vivo Transport and Lysosomal Trapping
To develop a mechanistic mathematical model for analysis of in vitro permeability assays that accounts for all mechanisms contributing to observed apparent permeability: passive paracellular and…
A Computational Drug-Target Network for Yuanhu Zhitong Prescription
Yuanhu Zhitong prescription (YZP) is a typical and relatively simple traditional Chinese medicine (TCM), widely used in the clinical treatment of headache, gastralgia, and dysmenorrhea.
Virtual Screening and Biological Evaluation of Inhibitors Targeting the XPA-ERCC1 Interaction
Nucleotide excision repair (NER) removes many types of DNA lesions including those induced by UV radiation and platinum-based therapy.
Modeling drug- and chemical-induced hepatotoxicity with systems biology approaches
We provide an overview of computational systems biology approaches as applied to the study of chemical- and drug-induced toxicity.
Simulations Plus Announces Accelerated Quarterly Cash Dividend
Company declares accelerated cash dividend of $0.14 per share
Don’t shoot.
Criminologist David M. Kennedy’s (1) strategy for reducing gang violence has dramatically reduced youth homicide rates nationwide. Dubbed the “Boston Miracle,” this strategy brings together all the key actors in a neighborhood from the police and community members to gang members, drug dealers, and their mothers and grandmothers to openly discuss their issues. Boston’s youth murders were cut by two thirds after installation of the program (2).
Simulations Plus Reports Preliminary Revenues for First Fiscal Quarter FY2013
Revenues Increase 1.9% for New Record 1st Quarter
Toxicity Webinar
Simulations Plus offers a rapidly growing array of accurate predictive models in ADMET Predictor™, focused on toxicity endpoints deemed important by regulatory agencies.
Modeling and simulation of the effect of proton pump inhibitors on magnesium homeostasis: part I. oral absorption of magnesium
Prolonged use of proton pump inhibitors has reportedly caused rare clinically symptomatic hypomagnesemia.
Application of ED-optimality to screening experiments for analgesic compounds in an experimental model of neuropathic pain
In spite of the evidence regarding high variability in the response to evoked pain, little attention has been paid to its impact on the screening of drugs for inflammatory and neuropathic pain.
Optimised protocol design for the screening of analgesic compounds in neuropathic pain
We have previously shown how screening experiments for neuropathic pain can be optimised taking into account parameter and model uncertainty.
The Worst Job In Pharma
Being the Team Leader of an R&D team might not be down at the level of some of the jobs on Mike Rowe’s Dirty Jobs on TV’s Discovery Channel, but I nominate it as the worst job in Pharma.
Toxicological considerations of acetylcholinesterase reactivators
The more or less systematic studies on the specific activity of oximes as reactivators of acetylcholinesterase (AChE) inhibited by organophosphorus (OP) compounds...