“Thirty minutes until system shut-down” was the announcement over the loudspeaker that signaled the start of the move to new office space.
Simulations Plus Announces Another Quarterly Cash Dividend Increase
Cash dividend increased to $0.04 per share
Comparison of in silico models for prediction of mutagenicity
Using a dataset with more than 6000 compounds, the performance of eight quantitative structure activity relationships (QSAR) models was evaluated: ACD/Tox Suite, Absorption, Distribution...
U.S. FDA Adds Licenses of GastroPlus™ Software
Office of Clinical Pharmacology Interested in Program’s Drug-Drug Interaction Capabilities
Bayer pKa Collaboration Webinar
In this webinar, we present a new in silico multiprotic pKa prediction tool with upgraded functionality, improved prediction accuracy and significantly expanded applicability domain.
A Simplified PBPK Modeling Approach for Prediction of Pharmacokinetics of Four Primarily Renally Excreted and CYP3A Metabolized Compounds During Pregnancy
During pregnancy, a drug's pharmacokinetics may be altered and hence anticipation of potential systemic exposure changes is highly desirable.
Incorporation of Physiologically Based Pharmacokinetic Modeling in the Evaluation of Solubility Requirements for the Salt Selection Process: A Case Study Using Phenytoin
In the pharmaceutical industry, salt is commonly used to improve the oral bioavailability of poorly soluble compounds. Currently, there is a limited understanding on the solubility...
Validation of quantitative structure–activity relationship models to predict water-solubility of organic compounds
Water-solubility is an important physicochemical property in pharmaceutical and environmental studies. We assessed the performance of five predictive computer models: ACD/PhysChem History...
Is the full potential of the Biopharmaceutics Classification System reached?
In this paper we analyse how the biopharmaceutics classification system (BCS) has been used to date. A survey of the literature resulted in a compilation of 242 compounds for which BCS classes were reported.
Bioisosteric approach in designing new monastrol derivatives: an investigation on their ADMET prediction using in silico derived parameters
Medicinal chemists are facing an increasing challenge to deliver safer and more effective medicines. An appropriate balance between drug-like properties such as solubility, permeability, metabolic stability...
In vivo Dissolution and Precipitation
This webinar, hosted by the GastroPlus User Group, focuses on the simulation of in vivo dissolution and precipitation based on in vitro experimental data using GastroPlus, with the goal to provide better predictive oral absorption kinetics.
Profiling Biopharmaceutical Deciding Properties of Absorption of Lansoprazole Enteric-Coated Tablets Using Gastrointestinal Simulation Technology
The aim of the present study was to correlate in vitro properties of drug formulation to its in vivo performance, and to elucidate the deciding properties of oral absorption.
Tedizolid Population Pharmacokinetics, Exposure-Response, and Target Attainment
Tedizolid phosphate is a novel antibiotic prodrug rapidly converted by phosphatases to its active moiety tedizolid after administration. Tedizolid is 4-16 fold more potent in vitro than linezolid against…
What’s New in GastroPlus™ 8.5?
This webinar walks you through the new features and enhancements in GastroPlus version 8.5. Among the topics that will be covered: - new mechanistic model for in vivo precipitation kinetics...
Simulations Plus Reports Preliminary Revenues for Fourth Fiscal Quarter and Fiscal Year 2013
Full-Year Revenue Up 6.6%; 6th Consecutive Profitable Year
Utility of Physiologically Based Modeling and Preclinical In Vitro/In Vivo Data to Mitigate Positive Food Effect in a BCS Class 2 Compound
Physiologically based pharmacokinetic (PBPK) modeling has become a useful tool to estimate the performance of orally administrated drugs.
Amorphous solid dispersions and nano-crystal technologies for poorly water-soluble drug delivery
Poor water-solubility is a common characteristic of drug candidates in pharmaceutical development pipelines today. Various processes have been developed to increase the solubility, dissolution rate...
Oral delivery of anticancer drugs: Challenges and opportunities
The present report focuses on the various aspects of oral delivery of anticancer drugs. The significance of oral delivery in cancer therapeutics has been highlighted which principally includes...
Lead hopping and de novo design webinar
This webinar discusses details of lead hopping and de novo design with MedChem Studio™, and demonstrates the software's ability to generate new virtual structures quickly and easily.
Simulations Plus Releases GastroPlus™ 8.5
Software Upgrade Adds Numerous Capabilities and User Convenience Features